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Marmosets as a model organism: basic and advanced techniques

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Toshiaki Watanabe

Toshiaki Watanabe

National Center for Child Health and Development

Dr. Watanabe worked on germ cells in the new world monkey common marmoset, a model organism for studying human biology. He focused on primate spermatogonial stem cells (SSCs). The SSC system in primates is largely different from that in mice. Common marmosets are very useful for studying primate-specific mechanisms. He established a marmoset research group at National Center for Child Health and Development (NCCHD). Before joining NCCHD, he acquired techniques for handling marmosets and generation of genetically modified marmosets at the Central Institute of Experimental Animals, where marmoset has been studied for a long time since the 1980s. Dr. Watanabe made a transition from mouse research to primate research. In mice, Dr. Watanabe studied a small RNA-based retrotransposon suppression system (piRNA pathway) in mouse germ cells. In these studies, he published several papers in prestigious journals, including Nature and Science. Dr. Watanabe obtained a BSc from The University of Tokyo (2003) and a Ph.D. in Graduate School for advanced study (2009), and worked at several research institutes including the National Institute of Genetics (research associate, 2009-2010), Yale University (research fellow, 2010-2016), and Kyoto University (assistant professor 2016-2017).

Collection Overview

Mice are a significant model organism for studying mammalian development. The information obtained from mice helps us understand humans. However, there are significant differences in the biological mechanisms between mice and humans. Non-human primates serve to bridge the gap between these species. Primate biological mechanisms are largely unexplored, although understanding the mechanisms is essential for advancing human biology, which contributes to improving medicine and increasing our wisdom. Marmosets are an attractive model for studying primate development. They are small and relatively easy to handle. Developmental mechanisms are mostly shared between marmosets and humans, although initial developmental speed is somewhat delayed in marmosets. Furthermore, good foundations for studying biological and medical science (e.g., development, reproductive science, neuroscience, behavioral science, regenerative medicine, pharmacological science, and the development of new treatments) have been established in marmosets. Detailed fundamental methods, on the other hand, are frequently unavailable. This Methods Collection intends to help researchers get started with marmoset experiments. It will include a variety of fundamental techniques for experiments, such as the generation of genetically modified marmosets and husbandry (i.e., care, breeding, and artificial nursing). In addition, the collection will also include techniques for using marmosets as model organisms in biomedical research. Techniques linked to reproductive biology, stem cell biology, molecular biology, immunology, neuroscience, aging, behavioral science, toxicology, and other fields will be covered.

Articles

Hand-Rearing Method for Infant Marmosets
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Hand-Rearing Method for Infant Marmosets

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Cited by 1

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2023

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Abstracts

Hand-rearing method for baby marmosets

Rui Li1,

Hao Sun2,

Lixia Gao*2,

Xinjian Li*1

1Department of Neurology of the Second Affiliated Hospital and Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of Medicine,

2Department of Neurology of the Second Affiliated Hospital and Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of Medicine; Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument Science, Zhejiang University

In vitro follicular growth of marmoset ovarian follicle

Seung Yup Ku*1,

Yoon Young Kim*1

1Department of Obstetrics and Gynecology; Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul 03080, Korea