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Thoracic Transplantation Research Methods
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Guest Editor

Asvin Ganapthi

Asvin Ganapthi

Ohio State Wexner Medical Center

Asvin Ganapathi is an assistant professor of cardiac surgery at the Ohio State University Wexner Medical Center. He received his medical degree from Case Western Reserve University and completed general and cardiothoracic training at Duke University. He practices all aspects of adult cardiac surgery but specializes in heart and lung failure and transplant. From an academic perspective, he participates in clinical outcomes and translational research regarding thoracic transplantation.

Collection Overview

Thoracic transplantation is characterized as a rapidly changing field due to modifications in surgical techniques, the need for mechanical support, and changes in organ preservation. The purpose of this Methods Collection would be to invite thought leaders in thoracic transplantation to submit methods regarding innovations in surgical techniques (e.g., robotic lung transplantation, a novel method of biventricular assist device insertion) and research methods (e.g., use of perfusion devices for therapeutic modification, ex vivo lung perfusion to assess lung allograft function). The surgical techniques section will cover both heart and lung transplants.

The goal of these videos is to provide readers with an opportunity to visualize real-life surgical techniques that may apply to a research setting. The intent is to exhibit cutting-edge methodologies essential to heart and lung transplant research. Examples include large animal surgery, preservation techniques utilizing machine perfusion for heart and lung donor organs, and basic scientific components of large animal studies essential for advancing research in the field. Ultimately, this collection will serve as a hub for clinicians and researchers in thoracic transplantation to better understand the surgical procedures associated with heart and lung failure and translational/basic science methods to study them.

Articles

Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts
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Modified Langendorff Perfusion for Extended Perfusion Times of Rodent Cardiac Grafts

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Cited by 2

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2024

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Abstracts

Ex vivo rodent heart perfusion as a tool for cardiovascular research

Manuela Lopera Higuita1

1Massachusetts General Hospital/ Harvard Medical School

Assessment of coronary vasculature during ex situ heart perfusion

Julien Guihaire*1

1Cardiac Surgery, Marie Lannelongue Hospital, University of Paris Saclay, France

Abstract for: Organ Assessment and Optimization in a Large Animal Model of Ex-Vivo Heart Perfusion

George Olverson 1,

Manuela Lopera Higuita2,

Doug Vincent3,

Emmanuella Ajenu2,

Maya Bolger Chen4,

Nathan Minie1,

Joseph Catricala1,

Allison Disanto1,

William Michaud1,

David DAlessandro1,

Shannon Tessier2,

Alireza Rabi1,

Asishana Osho*1

1Division of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,

2Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,

3VentriFlo Inc, Pelham, NH, USA,

4enter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA