Thoracic transplantation is characterized as a rapidly changing field due to modifications in surgical techniques, the need for mechanical support, and changes in organ preservation. The purpose of this Methods Collection would be to invite thought leaders in thoracic transplantation to submit methods regarding innovations in surgical techniques (e.g., robotic lung transplantation, a novel method of biventricular assist device insertion) and research methods (e.g., use of perfusion devices for therapeutic modification, ex vivo lung perfusion to assess lung allograft function). The surgical techniques section will cover both heart and lung transplants.
The goal of these videos is to provide readers with an opportunity to visualize real-life surgical techniques that may apply to a research setting. The intent is to exhibit cutting-edge methodologies essential to heart and lung transplant research. Examples include large animal surgery, preservation techniques utilizing machine perfusion for heart and lung donor organs, and basic scientific components of large animal studies essential for advancing research in the field. Ultimately, this collection will serve as a hub for clinicians and researchers in thoracic transplantation to better understand the surgical procedures associated with heart and lung failure and translational/basic science methods to study them.
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2024
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Ali Akamkam1,2,3, Vincenzo Palermo4, Tiphaine Legrand5, Guillaume Fadel2,3,6, Benoît Decante2,3, Simon Dang Van2,3,7, Jean-Noel Andarelli4, Valérie Furlan5, Julien Guihaire1,2,3,8
1Department of Cardiovascular Surgery, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, 2Laboratory of Preclinical Research, Department of Research and Innovation, Groupe Hospitalier Paris Saint Joseph, 3Inserm UMR S 999, Pulmonary Hypertension: Pathophysiology and Novel Therapies, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, 4Department of Cardiology, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, 5Department of Pharmacology and Toxicology, AP-HP. University of Paris-Saclay, 6Department of Thoracic Surgery, Marie Lannelongue Hospital, Groupe Hospitalier Paris Saint Joseph, 7Department of Cardiovascular Surgery, University Hospital of Angers, 8University of Paris Saclay
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Cited by 7
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2024
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George Olverson IV*1, Manuela Lopera Higuita*2, Maya Bolger-Chen2, Emmanuella O. Ajenu2, Selena S. Li1, Hussein Kharroubi1, Bassel Tfayli1, Chijioke Chukwudi1, Nathan Minie1, Joseph Catricala1, Allison Pitti1, William Michaud1, Doug Vincent3, David D’Alessandro1, S. Alireza Rabi1, Shannon N. Tessier2, Asishana A. Osho1
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2026
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Shivani Shirodkar*1, T. Jake Samuel*2, Rachael Quinn1, Jessica B. Briscoe1, Yashutosh Joshi1, Joshua Fine1, AlleaBelle Bradshaw1, Dhruvi Mehta3, Andres F. Bermudez4, Jessica Herrera4, Katelyn Jackson4, Rohan Meda1, Hee Cheol Cho5, Michael Schär2, Chetan Pasrija1
1Division of Cardiac Surgery, Johns Hopkins University School of Medicine, 2Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Johns Hopkins University School of Medicine, 5Department of Pediatric Cardiac Surgery, Johns Hopkins University School of Medicine
Ex vivo rodent heart perfusion as a tool for cardiovascular research
Manuela Lopera Higuita1
1Massachusetts General Hospital/ Harvard Medical School
Assessment of coronary vasculature during ex situ heart perfusion
Julien Guihaire*1
1Cardiac Surgery, Marie Lannelongue Hospital, University of Paris Saclay, France
Abstract for: Organ Assessment and Optimization in a Large Animal Model of Ex-Vivo Heart Perfusion
George Olverson 1,
Manuela Lopera Higuita2,
Doug Vincent3,
Emmanuella Ajenu2,
Maya Bolger Chen4,
Nathan Minie1,
Joseph Catricala1,
Allison Disanto1,
William Michaud1,
David DAlessandro1,
Shannon Tessier2,
Alireza Rabi1,
Asishana Osho*1
1Division of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,
2Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA,
3VentriFlo Inc, Pelham, NH, USA,
4enter for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA