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CRISPR-Cas12 and Cas13-Based Methods for Disease Detection
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Avinash Kumar

Avinash Kumar

Indian Institute of Information Technology Design & Manufacturing Kanchipuram, Chennai

Dr. Kumar is a Visiting Assistant Professor at Stanford University in California, USA (94305). His primary research focus at Stanford University is "Theoretical and Experimental Quantification of Error in Enzyme Kinetics Parameter of CRISPR-Cas12 and Cas13." The main objective is to develop and release the capability of CRISPR for disease diagnosis and treatment, aiming to achieve more sensitive and accurate disease detection and cure. In addition to his work at Stanford University, he is also engaged in a parallel project involving the desalination of water using innovative micro-fluidic based mixers. He holds the position of an assistant professor at the Indian Institute of Information Technology, Design and Manufacturing (IIITD&M), Chennai.His research interests include fabrication technologies such as micro/nanofabrication, laser machining, surface engineering for MEMS, micro/nano-fluidics, bio-fluidics, bio-medical devices, and health care. Previously, he served as a post-doctoral fellow at the Indian Institute of Technology Kanpur until 2019. His post-PhD research experience includes a position as an early post-doctoral fellow at the Indian Institute of Technology Delhi. He also worked as a research associate at the Bio-MEMS and Micro-fluidics Laboratory, Indian Institute of Technology Kanpur, India, from August 2012 to November 2012. In 2013, they collaborated as a research associate with Prof. G. K. Ananthsuresh and Prof. Ashitava Ghoshal at the Robert Bosch Centre for Cyber-Physical Systems, Mechanical Engineering Department, Indian Institute of Science Bangalore.

Collection Overview

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionized the field of genomics, enabling precise editing of DNA sequences. Recent discoveries have revealed that CRISPR enzymes Cas-12 and Cas-13 can also serve as powerful diagnostic tools. The utilization of CRISPR Cas-12 and Cas-13-based methods for disease detection has the potential to revolutionize the field of diagnostics, offering rapid and accurate disease identification and greatly enhancing patient outcomes.

This Methods Collection aims to delve into the vast potential of CRISPR Cas-12 and Cas-13-based methods for disease detection and provide a roadmap for future research in this area. The primary objective is to provide a comprehensive overview of the current state of CRISPR Cas-12 and Cas-13-based disease detection methods. The collection will encompass discussions on the advantages and limitations of these methods, shedding light on their unique features. Additionally, the articles will outline promising avenues for further research by exploring the potential applications of CRISPR Cas-12 and Cas-13-based methods in clinical settings.

Articles

Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents
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Point-of-care CRISPR-based Diagnostics with Premixed and Freeze-dried Reagents

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Cited by 9

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2024

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