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TOPICAL COLLECTIONS

Aging in Neurodegenerative Diseases: Novel Methods and Techniques
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Sina Shadfar

Sina Shadfar

Macquarie University, Macquarie Medical School, Motor Neuron Disease Research Centre

Dr. Sina Shadfar is a Postdoctoral Research Fellow in the Cellular Biology and Therapeutics Team within the multidisciplinary Motor Neuron Disease Research Centre at Macquarie University. Dr. Shadfar received his master’s degree in neuropharmacology from the College of Pharmacy, Yeungnam University in South Korea, where he studied the role of neurotrophic factors in Parkinson’s and Alzheimer’s disease. He received his PhD in neurobiology at Macquarie Medical School, Macquarie University, Australia. During his PhD, Dr. Shadfar identified novel therapeutic strategies to enhance DNA repair in neurodegenerative diseases in both cells and in vivo models (zebrafish, rodents, and C. elegans). He was awarded 10 prestigious scholarships, awards, or international travel grants, including the Federation of European Neuroscience Societies and International Brain Organization's (FENS-IBRO) young investigators training grant. Dr. Shadfar has published a total of 25 articles in leading journals and presented at 20 national and international conferences in 7 different countries. His current research focuses on studying aging mechanisms and finding novel therapeutics based on modifying age-related pathways in neurodegenerative diseases, particularly in ALS/FTD. 

Collection Overview

Aging occurs due to stochastic damage accumulated in cells over many years. Additionally, it is a major risk factor for neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Besides increasing disease risk, aging exacerbates disease severity and impairs recovery after insults. As a result, targeting aging may hinder age-related neurodegeneration. Interventions addressing aging have shown promise in extending lifespan or health span in age-related diseases. However, the relationship between aging and neurodegeneration in neurodegenerative diseases remains unclear.

This Methods Collection aims to provide reproducible and standardized methodologies for studying age-related mechanisms, including DNA damage and genomic instability, telomere shortening, epigenetic alterations, proteostasis dysfunction, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion, and altered intercellular communication. Doing so aims to facilitate global access to current approaches, foster research collaborations, and ultimately establish an evidence-based approach to target age-related neurodegenerative disorders.

Articles

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Cited by 25

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2020

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Abstracts

The Application of Mobile-brain Body Imaging (MOBI) Technology to the Development of Neuro-Markers of Neurodegeneration in Aging

Jeehyun Kim1,

Edward G Freedman1,

Esteban Avendano1,

Paige R Nicklas1,

Victoria A Popov1,

David P Richardson1,

John J Foxe*1

1The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA