Aging occurs due to stochastic damage accumulated in cells over many years. Additionally, it is a major risk factor for neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Besides increasing disease risk, aging exacerbates disease severity and impairs recovery after insults. As a result, targeting aging may hinder age-related neurodegeneration. Interventions addressing aging have shown promise in extending lifespan or health span in age-related diseases. However, the relationship between aging and neurodegeneration in neurodegenerative diseases remains unclear.
This Methods Collection aims to provide reproducible and standardized methodologies for studying age-related mechanisms, including DNA damage and genomic instability, telomere shortening, epigenetic alterations, proteostasis dysfunction, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion, and altered intercellular communication. Doing so aims to facilitate global access to current approaches, foster research collaborations, and ultimately establish an evidence-based approach to target age-related neurodegenerative disorders.
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Cited by 25
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2020
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Tino Emanuele Poloni*1,4, Valentina Medici*1, Arenn Faye Carlos1, Annalisa Davin2, Arcangelo Ceretti1, Michela Mangieri1, Paola Cassini1,4, Roberta Vaccaro3, Daniele Zaccaria3, Simona Abbondanza3, Matteo Bordoni5, Valentina Fantini2,6, Elena Fogato7, Cristina Cereda5, Mauro Ceroni8, Antonio Guaita1,2,3
1Department of Neurology and Neuropathology, Golgi-Cenci Foundation, 2Laboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation, 3Department of Neuropsychology and Social Sciences, Golgi-Cenci Foundation, 4Department of Rehabilitation, ASP Golgi-Redaelli Geriatric Hospital, 5Genomic and Post-Genomic Center, IRCCS Mondino Foundation, 6Department of Brain and Behavioral Sciences, University of Pavia, 7Department of Pathology, ASP Golgi-Redaelli Geriatric Hospital, 8Department of Neurological Science, IRCCS Mondino Foundation, University of Pavia
The Application of Mobile-brain Body Imaging (MOBI) Technology to the Development of Neuro-Markers of Neurodegeneration in Aging
Jeehyun Kim1,
Edward G Freedman1,
Esteban Avendano1,
Paige R Nicklas1,
Victoria A Popov1,
David P Richardson1,
John J Foxe*1
1The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA