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Novel Medical Techniques for Cardiovascular Neuromodulation
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Naveen Jayaprakash

Naveen Jayaprakash

Feinstein Institutes for Medical Research

Dr. Jayaprakash completed his B.Tech in Biotechnology at Anna University, India, before pursuing his Master's and Ph.D. in Neuroscience at Central Michigan University. During his doctoral studies, he investigated the pre-symptomatic deficits of neurotransmitter levels in Huntington's disease and conducted in-vivo neurophysiological examinations of transplanted neuronal stem cells using Optogenetics and ontophoresis in awake animals. His research employed advanced techniques such as optogenetics and electrophysiology with iontophoresis to evaluate different transplant types' efficacy in host integration and behavioral associations.Following the completion of his Ph.D., Dr. Jayaprakash pursued his postdoctoral fellowship at Marquette University, where he honed his expertise in stem cell transplantation and dedicated his efforts to enhancing Corticospinal Tract Axon Regeneration through combined stem cell transplantation and gene therapy for the treatment of Spinal Cord Injury. He was recognized for his exceptional work in this field and was awarded the esteemed "Wings for Life" postdoctoral fellowship.Dr. Jayaprakash is a Staff Scientist at the Feinstein Institutes for Medical Research. His primary focus is unraveling the intricate anatomical organization of vagal fibers within the human vagus nerve, specifically emphasizing their arrangement based on organ- and function-specific properties. His research has profound implications for developing groundbreaking therapeutic devices that modulate electrical activity in the vagus and other nerves. By precisely targeting the fibers that innervate specific organs, Dr. Jayaprakash's research aligns closely with the mission of SPARC, which aims to improve patient outcomes through innovative neuromodulation approaches.   

Collection Overview

Cardiovascular diseases persist as a significant global burden, necessitating continuous advancements in understanding their intricate mechanisms and fostering innovative treatment strategies.

Neuromodulation therapies are an emerging non-pharmacological approach for treating several disease conditions. The main concept is to enhance or reduce the neural activity responsible for the disease pathophysiology using neuro-cardiac medical devices. The fascinating subject is the autonomic nervous system (ANS), which maintains the body's homeostasis. The disruption of its integrity at any level contributes to the development and progression of many diseases, including those affecting the cardiovascular system.


The advancement in neuromodulation provides fascinating tools, such as vagus nerve stimulation and ablation technology, which have significantly broadened the applications of neuromodulation. However, several challenges, such as selectively stimulating nerve fibers, must be explored and resolved. The major hurdle lies in the lack of understanding, information sources, and hands-on experience required for cardiovascular neuromodulation.

This Methods Collection aims to bridge knowledge gaps and promote novel techniques to perform cardiovascular neuromodulation, ranging from tissue histology to medical device implantation. The collection will provide detailed approaches to safely and efficiently perform cardiovascular neuromodulation.

Articles

Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver
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Software for Analysis of Heart Rate and Blood Pressure Time-series Data from the Valsalva Maneuver

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2025

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