Cardiac arrhythmias significantly contribute to cardiovascular morbidity and mortality, imposing a substantial and ever-growing socio-economic burden. Despite extensive study in recent years, the underlying pathophysiology of different arrhythmia syndromes often remains unclear, leading to insufficient and primarily symptomatic treatment. There is a pressing need for further research into arrhythmia pathophysiology.

However, translating findings from animal models to clinical trials and developing new treatments remains challenging. Improving patient care relies on specialized, focused translational research to unravel pathophysiology, develop new causal treatments, and implement risk stratification strategies to guide individualized treatment.

This JoVE Methods collection offers a comprehensive toolkit of state-of-the-art strategies and methods in translational electrophysiology, bridging the gap from bench to bedside.

Potential topics covered in the collection include, but are not limited to:

• Investigating molecular, cellular, tissue, and whole-organism mechanisms of arrhythmia across species.
• Creating different animal models to research specific arrhythmia syndromes.
• Establishing workflows to characterize the animal models.
• Analyzing biosignals to facilitate risk stratification and guide treatment decisions.
• Developing strategies to translate research findings from bench to bedside, such as human validation of biosignals and drug targets.
• Implementing current findings in clinical practice to improve patient outcomes.

By addressing these topics, this JoVE Methods collection aims to facilitate advancements in the field of translational electrophysiology, ultimately leading to a better understanding and management of cardiac arrhythmias.