The landscape of epilepsy surgery has undergone significant transformations in recent years, particularly in presurgical evaluation and surgical approaches. Many medical centers worldwide have shifted their focus from subdural grid evaluation to more comprehensive sampling techniques, such as stereoelectroencephalography (SEEG), which allow for a less invasive yet more thorough assessment of the networks involved in seizure generation.  

Furthermore, the integration of multiple imaging techniques has been pivotal in enhancing the evaluation process. Traditional resection and ablative procedures have been significantly refined. Notably, improving the methodology and indications for functional hemispherectomy. The adoption of minimally invasive and precisely targeted ablative techniques, such as laser ablation and radiofrequency thermocoagulation, has gained significant traction. 

The field of epilepsy surgery is witnessing the emergence of targeted focal gene therapy for specific epilepsy pathologies, including a new trial for gene therapy in hippocampal sclerosis, as well as stem cell therapy. These innovative approaches for targeting specific pathologies are novel in epilepsy and hold immense potential for advancing treatment options. It is crucial to disseminate information about these advancements to the broader community, as it will significantly contribute to the progress of the field. 

Given these exciting developments, we propose a JoVE Methods Collection focusing on surgical epilepsy techniques. This collection would feature a series of videos and written reports, providing comprehensive insights into presurgical evaluation, surgical interventions, and precision medicine approaches for treating drug-resistant focal epilepsies. By showcasing these techniques, we aim to foster collaboration and facilitate the advancement of epilepsy surgery.