Methods for Studying Chronic Cough and Airway Inflammation

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Guest Editor

Zheng Deng

State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Dr. Zheng Deng is an associate researcher of the State Key Laboratory of Respiratory Diseases in Guangzhou Medical University. He obtained his doctoral degree in respiratory physiology/pharmacology from Pekin University in 2014. He began his work as a postdoctoral candidate in respiratory diseases at Guangzhou Medical University. His main research direction is the pathogenesis of cough and asthma. Dr. Deng has made significant contributions to respiratory research, notably discovering the positive impact of interferon-gamma (IFN-γ) on cough sensitivity (AJRCCM, 2018). His subsequent findings in AAIR (2022) highlighted IFN-γ's role in inducing pulmonary lymphocytic inflammation. Further insights, as published in Int.Immunopharmacol (2023) revealed lymphoid tissue proliferation with intrapulmonary IFN-γ instillation. Dr. Deng also linked elevated pulmonary IFN-γ levels to chronic refractory cough (Thorax, 2022), showcasing his impactful research in the field. He has successfully led and contributed to two National Natural Science Foundation of China projects and four additional scientific research endeavours. Furthermore, his dedication has resulted in the acquisition of two national invention patents in China.

Collection Overview

Chronic cough is common in respiratory clinics. A chronic cough is a persistent cough that lasts more than eight weeks. While cough is a symptom that can be associated with several lung diseases and some non-lung conditions, chronic cough may persist even after treating the underlying condition. Sometimes, it may still persist even after other diseases have been ruled out. Although chronic cough patients do not have any marked findings on a chest X-ray examination, airway inflammation always exists in these patients. It is essential to master the methods for studying chronic cough and airway inflammation to achieve a complete understanding of the mechanisms of chronic cough and airway inflammation. This Methods Collection strives to describe a set of critically important and complementary techniques that may be used to accomplish these goals. The collection primarily focuses on the peripheral mechanisms of chronic cough.

Articles

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Methods for Detecting Cough and Airway Inflammation in Mice

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Cited by 1

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2024

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Wenbin Ding¹, Mengxi Luo¹, Zhengyang Lin¹, Zheng Deng^1,2

¹State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, ²Guangzhou National Laboratory

Abstracts

Establishment of a mouse model with cough hypersensitivity via inhalation of citric acid

Mingtong Lin¹,

Chen Zhan¹,

Tingting Xu¹,

Jinlan Gu¹,

Chuqin Huang^*1

¹State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China