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Current Methods in Investigating the Role of Immune Cells in Cardiovascular Related Diseases from Animal Models to Human Patients

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Alexander Widiapradja

Alexander Widiapradja

University of Sydney

Dr. Alexander Widiapradja received his Bachelor of Science with Honours from the University of Queensland, Australia in 2009. He then obtained a PhD in Biomedical Science from the University of Queensland in 2014. In 2015 he joined the laboratory of Dr. Barbara Rolfe at the Australian Institute of Bioengineering and Nanotechnology (AIBN) as a postdoctoral fellow studying the role of complement system in melanoma tumorigenesis. From there, in 2016 he joined the research team of Associate Professor Scott Levick at the Medical College of Wisconsin (MCW) in the United States as an MCW Presidential Post-doctoral Scholar. In 2017, Dr. Widiapradja relocated to the Kolling Institute for Medical Research at the University of Sydney/Royal North Shore Hospital in Australia to take a position as Research Fellow. Dr. Widiapradja’s research interests include understanding the contributions of the neuropeptide substance P, as well as the orphan nuclear receptor Nr4a1, in cardiovascular biology. Of particular interest is how these effector molecules interact with the immune system, including macrophages and mast cells, to induce cardiac fibrosis.

Collection Overview

Cardiovascular diseases are ranked amongst the highest cause of death worldwide, with heart failure being the major contributor. Regardless of the aetiology, recent discoveries reveal that our immune system plays a major role in many cardiac disease progressions and ultimately influences the eventual outcomes. Thus, this sheds a light on the paramount importance of studying immune cells in cardiac diseases, from the cellular level to its effects as a whole cardiac-immune interaction in human patients. However, due to their relatively low population and complex functions in the heart, investigating cardiac immune cells have proven to pose a great challenge for many researchers. This methods collection will explore the recent techniques researchers use to effectively study the role of cardiac immune cells in various cardiac diseases, from extraction techniques to screening methods in cell-based studies, animal models to human patients, therefore providing access to cardiac researchers to share learning resources with each other and further advance this particular field of study in cardiovascular research.

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Cited by 24

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2021

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Abstracts

Immune cells and reactive oxygen species in cardiovascular disease

Chia-chi Liu*1

1Heart Research Institute, Australia; University of Sydney, Kolling Institute of Medical Research, Royal North Shore Hospital, Australia