
Cardiovascular diseases are ranked amongst the highest cause of death worldwide, with heart failure being the major contributor. Regardless of the aetiology, recent discoveries reveal that our immune system plays a major role in many cardiac disease progressions and ultimately influences the eventual outcomes. Thus, this sheds a light on the paramount importance of studying immune cells in cardiac diseases, from the cellular level to its effects as a whole cardiac-immune interaction in human patients. However, due to their relatively low population and complex functions in the heart, investigating cardiac immune cells have proven to pose a great challenge for many researchers. This methods collection will explore the recent techniques researchers use to effectively study the role of cardiac immune cells in various cardiac diseases, from extraction techniques to screening methods in cell-based studies, animal models to human patients, therefore providing access to cardiac researchers to share learning resources with each other and further advance this particular field of study in cardiovascular research.
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Cited by 24
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2021
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Eunbee Park1, Megan A. Evans4, Heather Doviak4, Keita Horitani4, Hayato Ogawa4, Yoshimitsu Yura4, Ying Wang2, Soichi Sano3,4, Kenneth Walsh1,4
1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, 2Department of Cardiology, Xinqiao Hospital, Army Medical University, 3Department of Cardiology, Osaka City University Graduate School of Medicine, 4Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
Immune cells and reactive oxygen species in cardiovascular disease
Chia-chi Liu*1
1Heart Research Institute, Australia; University of Sydney, Kolling Institute of Medical Research, Royal North Shore Hospital, Australia