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TOPICAL COLLECTIONS

Current Methods for the Detection and Treatment of Musculoskeletal Diseases
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Guest Editors

Qian Chen

Qian Chen

Warren Alpert Medical School, Brown University

Dr. Qian Chen is the Michael G. Ehrlich, MD Endowed Chair in Orthopaedic Research, Professor of Medical Science, and Vice Chair for Research in the Department of Orthopaedics at the Warren Alpert Medical School of Brown University. He received his PhD degree in Cell, Molecular, and Developmental Biology from Tufts University School of Medicine in Boston, and performed Post-Doctoral Fellowship at Harvard Medical School and Massachusetts General Hospital. Dr. Chen’s research interest includes cartilage molecular biology, aging and development, extracellular matrix, epigenetics and RNAi, mechano-transduction, osteoarthritis, nanomedicine and gene therapy. Throughout Dr. Chen’s research career, he received the Independent Scientist Award from NIH, the Satterfield Arthritis Investigator Award from Arthritis Foundation, and the Kappa Delta Award from American Academy of Orthopaedic Surgeons. Dr. Chen also served on multiple NIH study sections and advisory panels, and on the review board of Veteran’s Administration. 

Yajun Liu

Yajun Liu

Warren Alpert Medical School, Brown University

Dr. Yajun Liu is an instructor in research in the lab of Dr. Qian Chen in the Department of Orthopaedics at the Warren Alpert Medical School of Brown University and Rhode Island Hospital. She received her Ph.D. in Molecular, Cellular, and Developmental Biology from The Ohio State University. Dr. Liu joined the Chen lab as a Post-Doctoral Fellow after graduation to work on musculoskeletal diseases focusing on osteoarthritis. Her main research areas include understanding the molecular mechanisms for osteoarthritis pathogenesis, investigating sex dimorphism associated with aging diseases, aging disease prevention and treatment. In addition to that, Dr. Liu is especially interested in the fundamental biology of cell senescence and how it affects aging. 

Collection Overview

Musculoskeletal diseases (MSDs) include various conditions affecting muscles, bones, joints, and connective tissues. These conditions lead to pain and loss of function, often associated with aging. Common types of MSDs include osteoarthritis, rheumatoid arthritis, osteoporosis, bone fractures, and sarcopenia.  

MSDs can cause symptoms that affect various parts of the body, such as the neck, shoulder, wrist, back, hip, leg, knee, and foot. Depending on the severity, MSDs may even interfere with everyday activities like walking and a limited range of motion. The risk factors for developing MSDs include age, lifestyle, and family history.  

MSDs are the most common cause of chronic pain and affect more than 50 million US adults. Thus, early detection and diagnosis of the symptoms are essential. Currently, medications and non-pharmacologic treatments are available to relieve the pain caused by MSDs. However, methods to prevent and treat MSD pathogenesis from a mechanistic perspective are still under investigation.  

This Methods Collection aims to provide the most up-to-date methodologies to detect, diagnose, and treat various musculoskeletal diseases, especially during the early stages of disease progression.

Articles

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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2025

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Abstracts

Genicular Artery Embolization for the Treatment of Refractory Osteoarthritis Related Knee Pain

Yan Epelboym*1,

Ali Guermazi2

1Instructor of Radiology, Department of Radiology, Brigham and Women's Hospital,

2Professor of Radiology, Boston University School of Medicine

Uncontrolled Blood Glucose's Effect on Older Adults' Inflammation and Knee Osteoarthritis Symptoms

Sumaiyah Mat*1

1Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

The Passive Flexion External Rotation (PFER) test for Femoro-Acetabular Impingement Syndrome: Technique and preliminary report

Nick Mohtadi*1

1University of Calgary Sport Medicine Centre