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Experimental Animal Models for Biomedical Research
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Gulten Ates Ulucay

Gulten Ates Ulucay

Istanbul Yeni Yuzyil University

<p><span style="color: rgb(0, 0, 0);">Dr. Gulten Ates Ulucay is an assistant professor in the field of Physiology at Istanbul Yeni Yuzyil University, Faculty of Medicine. She has been focusing her studies on sepsis and experimental medicine since her postgraduate education. Dr. Ates&nbsp;who completed her master's and doctorate education in the Department of Physiology, Istanbul Faculty of Medicine, Istanbul University and continues her studies with her team in the university, has conducted many studies such as inflammatory pathways in sepsis, oxidant-antioxidant system, mitochondrial complexes, sepsis-related muscular damage, multiple organ damage and failure, apoptosis, profiling of electrolytes, trace elements and high-energy components in various tissues in sepsis, sepsis-related encephalopathy and the definition and effectiveness of the cholinergic anti-inflammatory pathway. She has also used many therapeutic pathways such as antioxidant, anti-inflammatory and stimulation of the cholinergic anti-inflammatory pathway as targets. She continues to work on sepsis models in experimental animals using many molecular techniques and imaging methods.</span></p>

Collection Overview

Experimental animal models are invaluable for creating treatment models and developing biomarkers and diagnostic measures. Nearly 89% of Nobel Prizes awarded in Medicine and Physiology, one of the most prestigious science awards, have been based on animal studies, emphasizing the leading role of this field in making groundbreaking discoveries. Although humans and animals have distinct appearances, their anatomical, physiological, and genetic similarities provide an advantage for transferring these studies to the clinic. Using model organisms, inflammatory diseases such as sepsis, neurodegenerative diseases such as Alzheimer's, mood disorders such as schizophrenia and depression, and clinical cases like cancer and epilepsy are studied. These models include both spontaneous and inducible models, as well as genetic manipulations. The scope of this Methods Collection is to compile research involving the modeling of various diseases with experimental animals. 

Articles

Developing a Rat Model for Bipolar Disorder
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Developing a Rat Model for Bipolar Disorder

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Cited by 1

2025

Abstracts

An Ex Vivo Porcine Lumbosacral Model for Simulating Lumbar Durotomy and Developing Full-Endoscopic Dural Repair

Wen-Hsiang Chou1,

Jui-Jung Yang*2

1Department of Orthopedics, Cheng Hsin General Hospital, Taipei, Taiwan,

2Department of Orthopaedic Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan

Surgical Induction of Endometriosis in a Preclinical Swine Model via Autologous Endometrial Transplantation

Jae-Wook Jeong1,

kiho Lee*1

1University of Missouri

Establishment and characterization of improved base-editing in cultured pig cells

Xiangxing Zhu*1

1FOSHAN UNIVERSITY

A model of balloon-induced acute compressive upper cervical spinal cord injury in rats

yingna qi1

1Beijing Hospital of Traditional Chinese Medicine, Capital Medical University

The ageless heart; the naked mole-rat as a model of cardiac resilience in biomedical research

Rochelle Buffenstein*1

1Biological Sciences, University of Illinois Chicago, 845 W Taylor, Chicago, Illinois 60607

A Modular iPSC-Derived Platform for Multilineage Differentiation and Engineered Human Tissue Reconstruction

Eric Ramirez-Salazar1

1The Wistar Institute

Quantifying Alpha-Synuclein Proteotoxicity in Caenorhabditis elegans Muscle Using a Standardized Thrashing Assay

Javier Valle-Galisteo1,

Cristina Garcia-Gutierrez2,

Mercedes Perez-Jimenez2,

Manuel Munoz*2

1Olavide Neuron STX/Universidad Pablo de Olavide,

2Universidad Pablo de Olavide

Auditory Brainstem Response Assessment in Guinea Pigs for Preclinical Hearing Research

Ostap Orishchak*1,

Karina Theoret1,

Inabat Yermesheva1,

Hady Tall1,

Sam Daniel*1

1McGill Otolaryngology Sciences Laboratory, McGill University, Montreal, Quebec, Canada