Neuromuscular disorders encompass a broad range of inherited and acquired diseases that affect motor neurons, peripheral nerves, neuromuscular junctions, and muscle. Despite significant advances in diagnostics and supportive care, effective treatments remain limited for many conditions, though in recent years, rapid progress in genetics, molecular biology, and bioengineering has accelerated our understanding of these diseases and has helped us translate key discoveries into potential therapeutics.

This collection highlights the diversity in model systems and analytic strategies used in research on neuromuscular disorders, bridge the gap between bench and bedside. We welcome methods-based studies and original research exploring disease mechanisms, therapeutic targets, and biomarker discovery across various neuromuscular conditions, including motor neuron diseases, muscular dystrophies, myopathies, and peripheral neuropathies. Studies using animal models, iPSC-derived systems, organoids, and computational approaches are also encouraged, as are those employing gene therapy, RNA-based therapeutics, cell-based treatments, and small molecules. By bringing together work spanning models and methodologies, this collection aims to foster cross-talk between basic scientists and clinician-investigators, ultimately accelerating the development of more effective therapies for patients with neuromuscular disease.