Methods and Applications in Tuberculosis Research and Prevention

TOPICAL COLLECTIONS

Guest Editor

Jia Cui

Department of Microbiology of Basic Medical Sciences, Changzhi Medical College

Dr. Jia Cui earned her PhD from Shanxi University, China, in 2020 under the supervision of Professor Changxin Wu, a tuberculosis (TB) researcher with 15 years of experience at the University of Cambridge. She is currently an associate professor and master’s supervisor at Changzhi Medical College in China. Her doctoral research focused on human susceptibility to TB and disease pathophysiology using the Mycobacterium marinum–zebrafish model. Her current work centers on the pathogenicity of Mycobacterium tuberculosis (Mtb) and the mechanisms of TB pathogenesis, with a particular emphasis on Mtb–host immune system interactions. Building on these insights, she is also engaged in the development of novel anti-tuberculosis therapies.

Collection Overview

Tuberculosis is an ancient infectious disease caused by Mycobacterium tuberculosis. The Global Tuberculosis Report, published annually by the World Health Organization (WHO), documents how this disease claims hundreds of thousands of lives worldwide yearly. Even more concerning, drug-resistant strains are evolving at an alarming rate, while TB-HIV co-infections and tuberculosis cases associated with specific cancers continue to rise steadily.

Research on tuberculosis involves saving lives and ensuring public health security. Mycobacterium tuberculosis engages in an intricate battle with the human immune system. Deciphering this millennia-old battle between pathogen and host promises to yield critical breakthroughs in TB prevention and treatment. Concurrently, developing novel vaccines is important to compensate for the suboptimal protective efficacy of the BCG vaccine in adult populations. Furthermore, screening for host susceptibility genes and improving early clinical diagnosis are crucial for TB control. Ultimately, eliminating tuberculosis represents a vital milestone in achieving global health equity.

Articles

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Identification of Potential Anti-TB Candidates: A Step-by-Step Guide to Synthesis, MIC Determination, and Cytotoxicity Assessment in Mammalian Cells

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2026

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Alexia de Matos Czeczot*^1,2, Ariel Moura Maia*¹, Camili Zanella Zotti*¹, Guilherme Arraché Gonçalves*¹, Josiane Delgado da Paz*¹, Marcia Alberton Perelló*¹, Nicholas Kraether Roth*^1,2, Luiz Augusto Basso^1,2,3, Pablo Machado^1,2,3, Cristiano Valim Bizarro^1,2

¹Center for Molecular and Functional Biology Research, National Institute of Science and Technology in Tuberculosis, Pontifical Catholic University of Rio Grande do Sul, ²Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, ³Graduate Program in Medicine and Health Sciences, School of Medicine, Pontifical Catholic University of Rio Grande do Sul

Abstracts

Early-Stage Assessment of 4-Aminoquinoline Compounds for Anti-Tuberculosis Activity

Alexia Czeczot¹,

Josiane Paz¹,

Guilherme Goncalves¹,

Ariel Maia¹,

Nicholas Roth¹,

Marcia Perello¹,

Camili Zotti¹,

Luiz Basso¹,

Pablo Machado¹,

Cristiano Bizarro^*1

¹Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900 Porto Alegre, Rio Grande do Sul, Brazil.