New Methods and Advances in Ocular Drug Delivery Systems

TOPICAL COLLECTIONS

Guest Editor

Tejabhiram Yadavalli

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago

<p>Dr. Tejabhiram Yadavalli is an assistant professor in the Department of Ophthalmology and Visual Sciences at the University of Illinois at Chicago. He directs the Ocular Drug Discovery and Delivery Lab, where his research integrates material science, nanotechnology, and virology to develop novel drug delivery systems for treating ocular diseases. With a PhD in nanotechnology and postdoctoral training in ocular virology, Dr. Yadavalli has published over 50 scientific articles and contributed to multiple patents. His lab focuses on translational platforms that enhance therapeutic efficacy, reduce dosage frequency, and improve patient compliance in ocular conditions.</p>

Collection Overview

Effective drug delivery to the eye remains a significant challenge due to anatomical and physiological barriers that limit bioavailability. This JoVE Methods Collection will showcase innovative strategies in ocular drug delivery, ranging from sustained-release nanoparticles and contact lens-based delivery systems to microneedles and in situ gelling formulations. These methods promise to reduce dosing frequency, improve patient compliance, and enhance therapeutic outcomes for both anterior and posterior segment diseases.

This collection aims to visually and rigorously document reproducible methods in ocular pharmacology, formulation science, and preclinical testing that advance the field toward more effective treatments. By consolidating cutting-edge techniques and protocols, this collection will be a valuable resource for researchers, clinicians, and pharmaceutical developers interested in ocular drug development.

Articles

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Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits

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2026

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Cristina Romo-Valera^1,2, Jaime Etxebarria^1,2,3, Maddalen Rodriguez-Astigarraga^1,2, Noelia Andollo^1,2

¹Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country UPV/EHU, ²BEGIKER Ophthalmology Research Group, IIS Biobizkaia, ³Department of Ophthalmology, University Hospital of Cruces

Abstracts

Radiolabeling of monoclonal antibodies by non-invasive intraocular pharmacokinetics using in vivo and ex vivo molecular imaging in animals models

Andrea Cuartero Martinez¹,

Xurxo Garcia Otero²,

Noemi Gomez Lado³,

Francisco J Otero Espinar⁴,

Pablo Aguiar⁵,

Anxo Fernandez Ferreiro^*1

¹FarmaCHUSLab Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain,

²Molecular Imaging and Pharmacokinetic Modelling Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Spain,

³Molecular Imaging Group and Nuclear Medicine, Health Research Institute of Santiago de Compostela (IDIS), University Hospital Santiago de Compostela, Spain,

⁴Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Santiago de Compostela, Spain,

⁵Molecular Imaging and Pharmacokinetic Modelling Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela, Spain.

Photo-Crosslinked Gelatine–Riboflavin Hydrogels as Fillers for Corneal Wound Healing

Cristina Romo-Valera Noelia Andollo¹

¹Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain