During the COVID-19 and influenza pandemics, individuals with obesity experienced an increased risk of respiratory failure and death. As obesity rates continue to rise, understanding how dysregulated metabolism affects the response to infection is critical. Additionally, nutrient supplementation during infection remains poorly understood.
Further research is needed to determine how metabolism is regulated during infection using mouse models. This collection will include studies employing mouse models of infection in combination with measurements of food intake, weight changes, vital signs, and metabolomic profiles. Our methods integrate approaches from infectious disease and metabolism research to advance understanding of metabolic regulation during illness.
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2026
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1Department of Internal Medicine, University of Texas Southwestern Medical Center, 2Department of Molecular Biology, University of Texas Southwestern Medical Center, 3Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 4Department of Microbiology, University of Texas Southwestern Medical Center