The role of Wnt signaling in both cell development and carcinogenesis is crucial. Despite intense research of the pathway and its specific molecular elements in the past decades, it is still not fully understood. One of the problems is that the mammalian Wnt family consists of 19 secreted glycoproteins that are extremely promiscuous when it comes to receptor binding. Deregulation of Wnt signaling pathway molecules is associated with aggressive carcinogenesis and these molecules recently became therapeutic targets not just in carcinomas but in other diseases associated with inflammation and vascularization. A collection of sensitive and easy methods to identify and target Wnt molecules can offer better diagnostic techniques and therapy.