Teleost Species as a Tool for Regenerative Medicine

TOPICAL COLLECTIONS

Guest Editor

Pietro Cacialli

University of Geneva, Switzerland, Department of Pathology and Immunology

Dr. Pietro Cacialli is a maître assistant in the Department of Pathology and Immunology at the University of Geneva in Switzerland. He obtained his PhD in model organisms in biomedical and veterinary research, from the University of Naples Federico II, Italy in 2016. He then went on to receive his postdoctoral fellow at the University of Geneva for four and a half years before to become maître assistant in 2021. His research interests are in stem cell biology and neural regeneration. In his PhD study, Dr. Cacialli studied the role of neurotrophic factors and their receptors in neurogenic stem cell niche after a traumatic brain injury in zebrafish. In addition, during his postdoc (in laboratory of Pr. Julien Bertrand), to extend his study of the stem cell niche to another, better characterized system in the zebrafish: the hematopoietic stem cell (HSC) niche. He identified the role of new genes that regulate the proliferation of HSCs in zebrafish embryo and conserved during human fetal liver development.

Collection Overview

Regeneration is an interesting and fascinating biological process that can restore organs, tissues, and cells damaged by diseases or traumatic events. After these events, transplantation of the damage organ is the only salvation for the patients. Nevertheless, owing to the short life of organ donations and different effects, such as: pain, infection, bleeding and blood clots, the regenerative approach could represent a potential alternative to save the life of these patients. Moreover, over the past decade, several model organisms have been used to study the process of regeneration after an event of traumatic injury and teleost species (Danio rerio, Salaria pavo, Tilapia melanopleura, Cyprinus carpio, Carassius auratus, and very recently Poecilia latipinna) are a consistent group. The goal of this Collection is to show standardized protocols for organ or tissues injury in teleost species, and thus demonstrate the enormous benefits that can be gained by using these model animals in regenerative medicine.