This collection focuses on advancing aerosol generation, exposure systems, and characterization technologies to support complex formulations and high-precision applications.

Key areas include:

1. Innovative Aerosol Generation and Delivery Techniques

Safe handling of high-potency test items during aerosolization
Methods for generating aerosols from formulations sensitive to mechanical stress, such as biologics or powders with low glass transition temperatures
Device-based aerosol generation, including systems like pressurized metered-dose inhalers (pMDIs) and heat-not-burn tobacco devices
Low variability aerosol generation
In-vitro aerosol generation
Low-flow aerosol delivery

2. Enhanced Exposure System Design

Development and characterization of novel exposure systems (e.g., in vivo and in vitro systems) to improve control, reproducibility, homogeneity, and relevance of inhalation studies

3. Miniaturized Aerosol Characterization Tools

Development of compact, real-time instruments capable of continuously measuring aerosol constituents at the nanogram scale, enabling more precise and efficient monitoring and control

Wei Teck Tan