Visible Platform Trial
Visible Platform Trial - Related Videos
02:51
UV-Visible Spectroscopy for Monitoring Fibrin Clot Formation
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This video demonstrates the use of a UV-visible spectrophotometer for monitoring insoluble fibrin clot formation as a function of the change in the solution turbidity. The UV-visible spectrophotometer measures the solution’s absorbance over time, which represents the turbidity change due to the insoluble fibrin clot formation.
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Ultraviolet-Visible (UV-Vis) Spectroscopy
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Source: Laboratory of Dr. B. Jill Venton - University of Virginia Ultraviolet-visible (UV-Vis) spectroscopy is one of the most popular analytical techniques because it is very versatile and able to detect nearly every molecule. With UV-Vis spectroscopy, the UV-Vis light is passed through a sample and the transmittance of light by a sample is measured. From the transmittance (T), the absorbance can be calculated as A=-log (T). An absorbance spectrum is obtained that shows the absorbance of a...
02:35
The Water Maze with Platform Relocation: A Method to Assess Working Memory
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2023
In this video, we describe the Morris water maze test with platform relocation, a navigational task used to study working memory in rodents.
01:28
The Trial Balance
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Clinical Trials
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2023
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias. There are four phases in a clinical trial. A phase one...
FAQs
Keeping the escape platform above the water changes the task demands: the animal can use direct visual information rather than reconstructing a location from hidden environmental relationships. This makes performance less dependent on spatial memory. The trial therefore provides a behavioral comparison for interpreting poor performance on tasks requiring less obvious platform information.
Escape latency shows how quickly the animal reaches the visible platform, while swimming behavior provides additional information about how the task is performed. Considering both measures helps researchers evaluate whether performance reflects visual function, motor ability, motivation, or compliance with the task rather than treating time alone as a direct measure of memory.
Strong performance indicates that the animal can detect the platform and reach it under conditions that reduce reliance on hidden spatial relationships. This result can help separate sensory or locomotor problems from spatial learning and memory deficits. Conversely, difficulty locating an openly visible platform may complicate interpretation of performance on more memory-dependent maze tasks.
The animal is placed in the Morris water maze and must locate an escape platform that remains above the water surface. Researchers observe how long the animal takes to reach it and record relevant swimming behavior. These observations produce behavioral measures that can be used to evaluate task performance and possible sources of impairment.
Researchers use this control test when they need to determine whether weak performance in a water-maze task reflects a specific spatial learning or memory problem. Because the platform is openly visible, the trial assesses abilities that support task completion without relying as heavily on hidden environmental relationships. It is therefore useful for interpreting broader maze results.
Results from the trial help reveal whether an animal can see the escape target, swim effectively toward it, remain motivated to escape, and comply with the task demands. Escape latency and swimming behavior are interpreted together for this purpose. This context helps prevent sensory or locomotor impairments from being mistaken for genuine memory deficits.