Conformational Exchange
Conformational Exchange - Related Videos
01:20
Conformity
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2020
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group. Asch’s Original Study Solomon Asch conducted several experiments in the 1950s to determine how people are affected by the thoughts and behaviors of other people. In one study, a group of participants was shown a series of printed line segments of different lengths: a, b, and c. Participants were then shown a fourth line segment: x. They were asked to identify which...
08:55
A Minority of One: Conformity to Group Norms
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2023
Source: William Brady & Jay Van Bavel—New York University It is obvious that we are influenced by those around us, but in the early to mid 1900's, psychologists began to study how potent social influence can be on our thoughts and behaviors. Motivated in part by attempts to explain the behaviors of Nazi soldiers in World War II, one topic of considerable interest at the time in psychology was conformity, the phenomenon in which people match their attitudes, behaviors, or beliefs to group...
05:45
Capillary Electrophoresis-based Hydrogen/Deuterium Exchange for Conformational Characterization of Proteins with Top-down Mass Spectrometry
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Cited by 3 •
2021
Presented here is a protocol for a capillary electrophoresis-based hydrogen/deuterium exchange (HDX) approach coupled with top-down mass spectrometry. This approach characterizes the difference in higher-order structures between different protein species, including proteins in different states and different proteoforms, by conducting concurrent differential HDX and electrophoretic separation.
11:38
Heat Exchanger Analysis
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2023
Source: Alexander S Rattner and Christopher J Greer; Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA Heat exchangers transfer thermal energy between two fluid streams, and are ubiquitous in energy systems. Common applications include car radiators (heat transfer from hot engine coolant to surrounding air), refrigerator evaporators (air inside refrigerator compartment to evaporating refrigerant), and cooling towers in power plants...
02:06
Social Exchange Theory
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2020
We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003). People are motivated to maximize the benefits...
FAQs
Exchange rates and state populations are governed by different but related features of the energy landscape. Thermal fluctuations promote transitions, whereas the height of an energy barrier influences how readily one state converts into another. A state can therefore be less populated yet still dynamically important because its accessibility and interconversion rate may affect biochemical behavior.
Conformational exchange provides a way to connect molecular motion with allosteric regulation. If biochemical function depends on access to multiple structural states, shifts in their populations or exchange rates can change how a protein responds to a ligand or interaction. This perspective helps explain why a single structure may not capture the dynamic behavior relevant to regulation.
NMR is valuable because it can report on conformational dynamics rather than only on a predominant structure. In particular, measurements may reveal sparsely populated states that are difficult to observe directly, allowing researchers to consider hidden members of a molecule’s conformational ensemble when relating molecular behavior to biochemical function.
An investigation begins by using NMR measurements to look for dynamic behavior associated with interconversion among states. Researchers can then characterize the observed exchange in terms of state populations and exchange rates while considering the energy barriers that separate states. This analysis can show whether a molecule samples minor states that may be relevant to its biochemical activity.
Such analysis is useful when researchers need to relate molecular flexibility to ligand binding, allosteric regulation, molecular recognition, or catalysis. It can also assess how a mutation, interaction, or environmental condition changes biochemical activity by affecting the molecule’s dynamic behavior. The resulting perspective complements structural information by showing how motion contributes to function.
A single model emphasizes one three-dimensional arrangement, whereas exchange analysis considers populations and rates connecting multiple states. That distinction matters when ligand binding, molecular recognition, allosteric regulation, or catalysis depends on flexibility. Conformational exchange therefore adds a dynamic layer to structural interpretation, helping researchers assess functions that may not be apparent from one predominant shape.