Hypodermic Needle Modification
Hypodermic Needle Modification - Related Videos
08:15
Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications
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Cited by 5 •
2017
The fabrication method for fine interdigitated electrodes (gap and width: 20 µm) at the tip of a hypodermic needle (diameter: 720 µm) is demonstrated using a spray coating and flexible film photomask in the photolithography process.
02:32
Histone Modification
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2020
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression. Acetylation The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
02:25
Spreading of Chromatin Modifications
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2020
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex. Writers The writer is an enzyme that can...
09:51
Intraosseous Needle Placement
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2023
Source: Julianna Jung, MD, FACEP, Associate Professor of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA For unstable patients requiring urgent administration of medications, fluids, or blood products, establishing vascular access quickly is essential. However, there are many factors that can complicate placement of a peripheral intravenous cannula (PIV), and it is extremely common for PIV attempts to fail. PIV placement may be technically challenging in small...
08:25
Needle Thoracostomy
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2015
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A tension pneumothorax is a life-threatening situation in which excess air is introduced into the pleural space surrounding the lung, either through trauma to the chest cavity or as a spontaneous leak of air from the lung itself. Air trapped within the pleural space causes separation of the lung from the chest wall, disrupting normal breathing mechanisms. Pneumothorax may be small without...
FAQs
Tip profile, bevel geometry, and lumen dimensions are central design variables. The tip and bevel influence how the needle enters tissue and how much tissue disruption may occur, while the lumen affects fluid movement during delivery or collection. Evaluating these features together helps bioengineers examine mechanical performance without separating insertion behavior from fluid-handling requirements.
Changing the bevel may modify insertion force and tissue interaction, whereas changing the lumen can influence flow behavior. These effects are connected because a design optimized for easier entry may not provide the same fluid-handling performance as another design. Comparing both properties allows researchers to identify geometries suited to controlled administration or biosampling.
Surface coatings and material choices affect how the needle interacts with biological systems in addition to its mechanical behavior. Their evaluation is therefore relevant to biological compatibility, tissue interaction, and reliable use in injection or sampling procedures. In bioengineering, these variables help researchers balance the physical demands of the device with its biological setting.
A successful redesign must balance insertion force, tissue disruption, flow behavior, delivery or collection needs, reliability, and biological compatibility. Improving one characteristic may require evaluating its effects on the others rather than treating performance as a single measurement. This systems-level comparison supports minimally invasive technologies intended to function consistently during biological procedures.
Researchers can compare the selected geometry, surface, or material against the intended delivery or collection task, then examine insertion force, flow behavior, tissue disruption, and reliability. The results can be interpreted alongside biological compatibility and patient-comfort considerations. This evaluation links measurable needle performance with the requirements of a specific bioengineering application.
Modification is useful when a conventional needle does not provide the needed control over administration, sampling, tissue interaction, or device integration. Designs may be tailored for controlled drug delivery, biosampling, injection-based procedures, or connection with specialized medical devices. The relevant design choice depends on whether the priority is mechanical performance, fluid handling, comfort, or compatibility.
Studies can show how specific changes influence insertion force, flow behavior, tissue disruption, delivery, sample collection, and reliability. These outcomes help researchers determine whether a design meets the demands of minimally invasive use and whether its biological interactions remain acceptable. Such evidence also supports comparisons among needle configurations within specialized medical-device development.