Microfluidic Delivery

Microfluidic delivery is the controlled transport of fluids, particles, cells, or therapeutic molecules through channels typically scaled to micrometers, enabling precise handling in bioengineering and biomedical research. Devices regulate pressure-driven or electrokinetic flow, while laminar fluid behavior, microscale mixing, and channel geometry govern how materials move, combine, and reach specific destinations. This control supports targeted drug and gene delivery, cell manipulation, droplet-based assays, and lab-on-a-chip systems that use small sample volumes. By improving transport precision, reducing reagent consumption, and enabling automated processing, microfluidic delivery contributes to diagnostic platforms, tissue engineering, and emerging personalized medicine technologies.

Microfluidic Delivery - Related Videos

Research

JoVE Journal - Bioengineering

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

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Cited by 40 •

2013

Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This protocol provides detailed steps on how to use the system for a broad range of applications.

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Cited by 1 •

2009

A novel microfluidic system has been developed using the phenomenon of passive pumping and a user controlled fluid delivery system. This microfluidic system has the potential to be used in a wide variety of biological applications given its low cost, ease of use, volumetric precision, high speed, repeatability and automation.

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

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Cited by 26 •

2017

Multilayer microfluidic devices often involve the fabrication of master molds with complex geometries for functionality. This article presents a complete protocol for multi-step photolithography with valves and variable height features tunable to any application. As a demonstration, we fabricate a microfluidic droplet generator capable of producing hydrogel beads.

Applying Microfluidics to Electrophysiology

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Cited by 1 •

2007

Microfluidics can be integrated with standard electrophysiology techniques to allow new experimental modalities. Specifically, the motivation for the ...

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