Nonlinear Fracture Mechanics

Nonlinear fracture mechanics is the study of crack initiation and growth when materials undergo substantial plasticity, viscoelasticity, damage, or other nonelastic deformation, making linear elastic assumptions inadequate. It characterizes fracture through energy dissipation, crack-tip fields, and parameters such as the J-integral or cohesive-zone behavior, which account for material deformation near the crack. In bioengineering, these principles help assess the failure of biomaterials, tissue-engineered constructs, prosthetic components, and soft biological tissues under complex loading. The resulting models support safer implant design, improved durability predictions, and better understanding of how material structure and physiological conditions influence fracture resistance.

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Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Nonlinear Pharmacokinetics: Causes of Nonlinearity

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2025

Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens. Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...

Research

JoVE Journal - Engineering

Measurement of Scattering Nonlinearities from a Single Plasmonic Nanoparticle

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Cited by 2 •

2016

Saturable and reverse saturable scattering were discovered in isolated plasmonic particles and adopted as a novel non-bleaching contrast method in super-resolution microscopy. Here the experimental procedures of detecting and extracting nonlinear scattering are explained in detail, as well as how to enhance resolution with the aid of saturated excitation microscopy.

Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation

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2026

The study innovatively combines sutures and titanium needles for stable internal fixation in a rat radial fracture model. Fracture healing was assessed via micro-computed tomography (micro-CT), and primary dorsal root ganglion (DRG) neurons were isolated and cultured for further investigation.

A Method for Studying the Temperature Dependence of Dynamic Fracture and Fragmentation

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Cited by 1 •

2015

Fracture and fragmentation are late stage phenomena in dynamic loading scenarios and are typically studied using explosives. We present a technique for driving expansion using a gas gun which uniquely enables control of both loading rate and sample temperature.

Introduction to Nonlinear Inequalities

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2025

Linear and nonlinear inequalities are fundamental for analyzing variable relationships and identifying ranges satisfying specific conditions. A linear inequality involves variables raised only to the first power, resulting in a straight-line graph. This line partitions the coordinate plane into two distinct regions: one that satisfies the inequality and one that does not. Each region represents a set of solutions where the linear relationship holds true under the specified constraint.Nonlinear...

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