Photoacoustic Wave Detection
Photoacoustic Wave Detection - Related Videos
09:52
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
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Cited by 14 •
2011
We have developed a flow cytometer using laser induced ultrasound to detect circulating melanoma cells as an early indicator of metastatic disease.
09:49
Photoacoustic Cystography
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2013
Photoacoustic cystography (PAC) has a great potential to map urinary bladders, a radiation sensitive internal organ in pediatric patients, without using any ionizing radiation or toxic contrast agent. Here we demonstrate the use of PAC for mapping urinary bladders with an injection of optical-opaque tracers in rats in vivo.
03:40
In Vitro Photoacoustic Flow Cytometry: A Non-invasive Flow Photoacoustic Technique to Detect Nanoparticle-bearing Circulating Ovarian Cancer Cells
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2023
In this video, we present a photoacoustic flow cytometric detection of ovarian cancer cells bearing nanoparticles in a circulating in vitro flow chamber. This non-invasive technique successfully identifies circulating tumor cells in a flow system utilizing a contrast agent.
08:38
Photoacoustic Tomography to Image Blood and Lipids in the Infrarenal Aorta
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2023
Source: Gurneet S. Sangha and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Photoacoustic tomography (PAT) is an emerging biomedical imaging modality that utilizes light generated acoustic waves to obtain compositional information from tissue. PAT can be used to image blood and lipid components, which is useful for a wide variety of applications, including cardiovascular and tumor imaging. Currently used imaging techniques have inherent...
08:31
Three-dimensional Optical-resolution Photoacoustic Microscopy
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Cited by 27 •
2011
Optical-resolution photoacoustic microscopy (OR-PAM) is an emerging technology capable of imaging optical absorption contrasts in vivo with cellular resolution and sensitivity. Here, we provide a visualized instruction on the experimental protocols of OR-PAM, including system configuration, system alignment, typical in vivo experimental procedures, and functional imaging schemes.
FAQs
The timing and duration of illumination shape how quickly energy is deposited and how clearly thermoelastic expansion can generate a detectable pressure wave. In tissue or another target, rapid expansion converts absorbed optical energy into acoustic information linked to the absorber. This relationship lets measurements reflect absorber distribution and concentration while the instrument records the resulting wave for analysis.
Detector response governs how pressure waves are converted into measurable signals. Its behavior therefore affects whether the recorded waveform faithfully represents the generated acoustic event and how confidently researchers interpret absorber location or concentration. In instrument development, evaluating detector response alongside signal processing is essential for turning physical wave generation into useful bioengineering measurements.
Optical methods contribute molecular specificity, whereas ultrasound contributes depth and spatial resolution. Combining these complementary strengths allows bioengineers to examine absorbers within tissue while retaining information tied to optical absorption. This is especially relevant when measurements must connect chromophore-related contrast with spatially resolved tissue structure.
A practical workflow starts by directing short laser pulses at tissue or a target chromophore. Absorbed energy produces rapid thermoelastic expansion, after which a transducer detects the resulting pressure waves. Signal processing then converts detector output into interpretable measurements related to absorber distribution and concentration. Each stage connects illumination, wave detection, and bioengineering analysis.
Researchers can use the measurements to investigate blood vessels, tissue oxygenation, and pigments. These targets illustrate how photoacoustic signals can report biologically relevant absorbers rather than only providing generic structural information. The resulting data support noninvasive imaging and monitoring in biomedical research, diagnostics, and other bioengineering studies.
Engineered materials can also serve as targets for photoacoustic measurements, extending the method beyond biological tissue targets. In bioengineering, this makes the technique relevant to studying designed materials alongside biological systems. Its value comes from relating optical absorption to detected acoustic signals, which can help characterize absorber distribution or concentration in the tested system.