Polyester Polymersomes
Polyester Polymersomes - Related Videos
06:01
Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
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Cited by 5 •
2021
Polymersomes are self-assembled polymeric vesicles that are formed in spherical shapes to minimize Gibb's Free Energy. In the case of drug delivery, more elongated structures are beneficial. This protocol establishes methods to create more rod-like polymersomes, with elongated aspect ratios, using salt to induce osmotic pressure and reduce internal vesicle volumes.
08:45
Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
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Cited by 5 •
2016
We present a protocol to rapidly form giant polymer vesicles (pGVs). Briefly, polymer solutions are dehydrated on dried agarose films adhered to coverslips. Rehydration of the polymer films results in rapid formation of pGVs. This method greatly advances the preparation of synthetic giant vesicles for direct applications in biomimetic studies.
10:27
The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
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Cited by 12 •
2016
Two types of surfaces, polyester-coated steel and polyester coated with a layer of silica nanoparticles, were studied. Both surfaces were exposed to sunlight, which was found to cause substantial changes in the chemistry and nanoscale topography of the surface.
09:47
Isolation and Compositional Analysis of Plant Cuticle Lipid Polyester Monomers
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Cited by 32 •
2015
Lipid polyesters constitute the structural components of two cell wall modifications, the plant cuticle and suberin-containing diffusion barriers. In this video, we describe a method to depolymerize cutin from whole delipidated leaves. The method can be applied to investigating mutants compromised in either cutin or suberin biosynthesis.
01:20
Types of Step-Growth Polymers: Polyesters
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2023
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes. Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
FAQs
Cargo location depends on its chemistry. Water-soluble molecules can occupy the vesicle’s aqueous core, while hydrophobic molecules can associate with the polyester-rich membrane interior. This dual-compartment organization gives the same carrier platform flexibility for transporting chemically different payloads, which is especially useful when a bioengineering design must combine aqueous compatibility with membrane-associated cargo.
Hydrolysis gradually breaks down the polyester chains within the membrane. As degradation proceeds, the membrane’s stability and permeability can change, allowing cargo release to develop over time rather than occurring only through an immediately open structure. This behavior provides a basis for coordinating payload availability with the intended duration of a delivery or biomaterial function.
A stable membrane helps retain encapsulated material, whereas permeability determines how readily molecules can move through the structure. Polyester polymersomes are valuable because these properties can be tuned rather than treated as fixed characteristics. Their balance affects retention, transport, degradation-linked release, and interactions with the surrounding biological environment.
A conceptual design sequence starts by selecting an amphiphilic polyester block copolymer and placing it in an aqueous environment. The hydrophobic and hydrophilic segments then organize into a bilayer arrangement, producing a membrane around an aqueous core. Researchers can select this architecture according to whether the intended cargo is water-soluble, hydrophobic, or both.
They are useful when a bioengineering system needs a biodegradable carrier that can accommodate different cargo types. Their aqueous core supports water-soluble molecules, while the membrane can associate with hydrophobic molecules. Tunable permeability and gradual polyester degradation further support designs aimed at controlling cargo release, making the platform relevant to both drug delivery and imaging.
In engineered biomaterials, the vesicles can provide a biodegradable compartment whose membrane properties and breakdown behavior influence biological interactions. Their ability to carry hydrophilic and hydrophobic molecules allows incorporation of varied functional payloads, while hydrolysis offers gradual loss of the polyester structure. These features make them relevant when a material must combine transport capacity with controlled degradation.