Precision Oncology
Precision Oncology - Related Videos
11:18
Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Cited by 5 •
2011
A thoracic oncology database was developed to serve as a comprehensive repository for clinical and laboratory data for the purposes of translational research. The database will serve translational cancer researchers within the Thoracic Oncology Research Program. This database is adaptable to other cancer models, as well as other human diseases.
06:37
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
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Cited by 41 •
2010
Fluorescence imaging is a promising innovative modality for image-guided surgery in surgical oncology. In this video we describe the technical procedure for detection of the sentinel lymph node using fluorescence imaging as showcased in gynecologic oncologicy. A multispectral fluorescence camera system, together with the fluorescent agent indocyanine green, is applied.
03:37
Uncertainty in Measurement: Accuracy and Precision
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2020
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Suppose a quality control...
07:05
The Precision of Visual Working Memory with Delayed Estimation
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Human memory is limited. Throughout most of its history, experimental psychology has focused on investigating the discrete, quantitative limits of memory—how many individual pieces of information a person can remember. Recently, experimental psychologists have also become interested in more qualitative limits—how precisely is information stored? The concept of memory precision can be both intuitive and elusive at once. It is...
01:52
Accuracy and Precision
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2025
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate measurements...
FAQs
Comparing tumor tissue with healthy tissue helps distinguish cancer-associated molecular changes from features of the patient’s normal biology. This contrast can clarify which genomic alterations, expression patterns, or biomarkers are relevant to diagnosis, prognosis, or treatment selection. The resulting interpretation supports more focused matching of therapies to tumor-specific vulnerabilities.
Precision oncology must account for tumor heterogeneity, meaning that different cells or regions within one tumor may not share identical molecular features. Tumor organoids provide models that help reproduce aspects of tumor behavior, allowing researchers to investigate heterogeneity and evaluate how treatments affect distinct tumor characteristics in experimental settings.
These measurements add information beyond the presence of a tumor by indicating molecular patterns associated with disease behavior or therapeutic vulnerability. When combined with genomic alterations and other tumor characteristics, they help clinicians and researchers prioritize targeted therapies or relevant clinical trials. Their value depends on interpreting tumor data in the context of the individual case.
A bioengineering workflow may pair high-throughput sequencing with microfluidic assays, biosensors, tumor organoids, and computational modeling. Sequencing characterizes molecular features, while organoids can help reproduce tumor behavior and the combined platforms can support treatment-response evaluation. Integrating experimental and computational tools connects tumor measurements with decisions about therapy and research design.
These platforms are especially useful when researchers need to investigate tumor behavior and treatment response in controlled experimental settings. Organoids can reproduce aspects of tumors, while microfluidic assays, biosensors, and computational models add complementary bioengineering approaches. Together, they support studies of tumor heterogeneity and drug response while helping researchers evaluate candidate therapies.
Beyond guiding treatment selection, precision oncology research can clarify why therapies fail, how tumors progress, and which molecular features may be associated with resistance. Engineered platforms and computational models make these questions experimentally approachable, while molecular analysis provides measurements that connect response patterns with tumor characteristics. These insights support therapy development and clinical-trial matching.