Pulsatile Flow
Pulsatile Flow - Related Videos
10:02
Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Cited by 12 •
2011
The following protocol outlines the process of isolating, ventilating and instrumenting mouse lungs to measure steady or pulsatile pulmonary vascular pressure-flow relationships in order to quantify the effects of blood flow, airflow, airway changes and vascular changes on right ventricular afterload.
11:22
Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor
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Cited by 32 •
2011
Our group has developed a bioreactor culture system that mimics the physiological pulsatile stresses of the cardiovascular system to regenerate implantable small-diameter vascular grafts.
08:08
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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Cited by 5 •
2015
Pulmonary hypertension is associated with a significant reduction in pulmonary artery pulsatility, contractility and elasticity, contributing to an increase in pulmonary artery pressure and pulmonary resistance. Using a hypoxic piglet model, this study demonstrated that improving pulmonary artery plasticity using a newly developed pulsatile catheter improves hypoxic pulmonary hypertension.
07:44
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
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Cited by 1 •
2023
This method describes the encapsulation of the rabies antigen into biodegradable polymeric microparticles with structural and material properties that enable pulsatile release after a predetermined delay. Enzyme-linked immunosorbent assay (ELISA) assessment of the antigen retrieved from the particle core confirms the presence of intact trimeric rabies virus glycoprotein through particle fabrication.
07:30
In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
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Cited by 6 •
2015
This protocol replicates physiological or pathological blood flow in vitro to aid in determining cell response in disease pathologies. By introducing a pressure damping chamber downstream of a blood pump, blood flow across the vasculature can be recapitulated and imposed on a monolayer of vascular endothelium or a mimetic co-culture.
FAQs
Cardiac contractions generate pressure waves that propagate through compliant blood vessels, while vessel resistance and elasticity modify how those waves move. Their interaction determines the resulting hemodynamic environment rather than allowing pressure or velocity to remain independent. In bioengineering studies, this coupling helps researchers examine how circulation behaves when fluid motion and vessel properties act together.
Resistance and elasticity influence how an imposed waveform is transmitted through a flow loop. Resistance affects opposition to fluid movement, whereas elasticity allows vessel walls to respond to changing pressure. Including both properties gives a model a closer representation of cardiovascular conditions and supports analysis of wall shear stress and fluid-structure interactions.
Constant-flow models do not reproduce the repeated changes associated with cardiac circulation. Pulsatile flow instead exposes a device or engineered vessel model to changing flow rate, pressure, or velocity, creating conditions described as physiologically relevant. This distinction matters when performance depends on the interaction between time-varying fluid motion and vessel or device behavior.
Researchers commonly build flow loops driven by programmable pumps. The pump imposes controlled, time-varying conditions so the loop can model cardiovascular circulation and its interaction with compliant vessels. Such systems provide a repeatable experimental setting for systematically investigating hemodynamics, wall shear stress, and fluid-structure interactions.
These models can reveal how changing fluid conditions affect hemodynamics, wall shear stress, and fluid-structure interactions. The outcomes connect the imposed flow pattern with responses at vessel walls and within engineered systems. Researchers can therefore assess whether a design behaves appropriately under varying cardiovascular conditions, rather than evaluating performance under a constant stream alone.
Flow models support the design and testing of vascular grafts, heart valves, and blood pumps by exposing these devices to changing cardiovascular conditions. They also extend to organ-on-chip systems, where controlled flow helps recreate relevant circulation-related environments. Across these applications, the goal is to evaluate device performance under conditions that better reflect physiological operation.