Vascular Structure
Vascular Structure - Related Videos
08:46
Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model
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Cited by 7 •
2018
Here, we present a modified electrospinning method to fabricate PCL vascular grafts with thick fibers and large pores, and describe a protocol to evaluate the in vivo performance in a rat model of abdominal aorta replacement.
11:10
Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice
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Cited by 3 •
2016
Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.
08:18
Engineered Vascularized Muscle Flap
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Cited by 6 •
2016
To date, thick tissue defects are typically reconstructed by applying autologous tissue flaps or engineered tissues. In this protocol, we present a new method for engineering vascularized tissue flap bearing an autologous pedicle, to serve as a substitute to autologous flaps.
08:22
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
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Cited by 37 •
2017
We provide a generalized protocol based on a microfluidic bioprinting strategy for engineering a microfibrous vascular bed, where a secondary cell type could be further seeded into the interstitial space of this microfibrous structure to generate vascularized tissues and organoids.
07:32
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
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Cited by 7 •
2014
The rodent retina has long been recognized as an accessible window to the brain. In this technical paper we provide a protocol that employs the mouse model of oxygen-induced retinopathy to study the mechanisms that lead to failure of vascular regeneration within the central nervous system after ischemic injury. The described system can also be harnessed to explore strategies to promote regrowth of functional blood vessels within the retina and CNS.
FAQs
The branching hierarchy separates the transport roles of larger and smaller vessels. Arteries and veins provide major routes through the circulatory network, while capillaries create the fine-scale interface associated with exchange between blood and tissues. In bioengineering, reproducing this organized arrangement can help engineered systems deliver oxygen and nutrients more effectively and remove waste from developing tissues.
Endothelial cells respond to pressure, shear stress, and chemical signals by regulating vessel diameter and permeability. These responses affect how readily blood moves through a vessel and how substances pass between the circulation and surrounding tissue. Bioengineered vascular systems therefore need to consider both physical forces and signaling conditions when modeling transport or tissue exchange.
Its value depends on the relationship between architecture and function. Vessel organization determines how blood is distributed, while endothelial regulation influences diameter and permeability. A bioengineered construct that reproduces channels without these structural and functional features may not support controlled transport or tissue exchange as effectively as one designed to reflect the coordinated behavior of native vascular structure.
Researchers incorporate vascular structure into engineered tissues and organoids to improve tissue survival and support controlled transport. The design may focus on recreating an organized vessel network and the endothelial functions that regulate exchange. This approach is relevant when developing three-dimensional biological models in which oxygen, nutrients, hormones, or waste must move through the tissue environment.
In vascular grafts, structural organization provides a basis for recreating the transport and regulatory features of blood vessels. Bioengineering efforts can use the architecture of arteries, veins, and capillaries as a framework while considering endothelial responses to pressure, shear stress, and chemical signals. The intended outcome is a graft design better suited to controlled blood flow and tissue interaction.
Microfluidic systems can recreate selected features of vascular architecture and provide a setting for studying transport, blood flow regulation, and tissue exchange. By incorporating organized channels and endothelial responses, these systems support controlled investigations that are difficult to represent with structure alone. Applications include cardiovascular disease studies, drug delivery research, and evaluation of regenerative medicine strategies.