Acne Pathogenesis
Acne Pathogenesis - Related Videos
01:27
Acne Infection
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2026
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
03:10
A Rat Model of Compound Acne
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Cited by 1 •
2024
This protocol outlines the procedure for inducing acne inflammation in rat skin with oleic acid and Cutibacterium acnes.
06:56
Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
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Cited by 10 •
2012
A rapid approach to investigate interactions and effects on molecular mechanisms related to the presence of antibodies in an intracellular environment is described. The method involves transfection of antibodies into live cells using a non-covalent complex formation based on a lipid formulation. The technique is adaptable to immortalized cell lines and primary cells.
01:20
Asthma: Pathogenesis and Management
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2024
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms. Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:23
Cystic Fibrosis: Pathogenesis
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2024
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body. CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
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Androgens stimulate sebum production within the pilosebaceous unit, increasing the lipid-rich material available inside follicles. This change does not act alone: its effects interact with abnormal follicular keratinization, which can restrict normal pore clearance. Studying both processes together helps explain why hormonal signaling and follicular biology are important starting points for acne research.
Abnormal follicular keratinization alters the normal turnover of cells lining the pore. When this process contributes to obstruction, sebum accumulates rather than moving freely through the follicle, creating the conditions associated with comedones. This mechanism connects a change in epithelial biology with a visible acne lesion and provides a rationale for investigating treatments that normalize follicular turnover.
Accumulated sebum creates a follicular environment that supports Cutibacterium acnes. Microbial signals can then interact with innate immune responses, shifting the process beyond simple pore obstruction toward inflammation. This interaction is biologically important because it helps account for inflammatory lesions such as papules and pustules, rather than treating microbial activity as an isolated cause.
Lesion development reflects the combined effects of follicular obstruction, sebum accumulation, microbial activity, and inflammatory signaling. Comedones represent one outcome of the obstructive process, whereas papules, pustules, and nodules reflect additional inflammatory involvement. Examining these mechanisms together gives biology researchers a framework for relating cellular events to the range of visible lesion forms.
A useful investigation follows the sequence from androgen-driven sebum production and altered follicular keratinization to obstruction, microbial support, innate immune signaling, and lesion formation. Researchers can then ask which stage changes when a particular biological process is regulated. This sequence provides a structured way to connect events in the pilosebaceous unit with acne outcomes.
The pathway identifies several research targets: reducing sebum production, normalizing follicular turnover, limiting Cutibacterium acnes activity, and reducing inflammatory signaling. These targets correspond to different stages of the biological sequence rather than representing interchangeable actions. Comparing them helps researchers evaluate whether an approach addresses obstruction, microbial support, inflammation, or more than one contributing mechanism.