Anti-roll Plate
Anti-roll Plate - Related Videos
11:04
Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
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Cited by 4 •
2013
This study used a multi-well plate microfluidic system, significantly increasing throughput of cell rolling studies under physiologically relevant shear flow. Given the importance of cell rolling in the multi-step cell homing cascade and the importance of cell homing following systemic delivery of exogenous populations of cells in patients, this system offers potential as a screening platform to improve cell-based therapy.
01:09
Rolling Without Slipping
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2023
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is essential...
01:14
Rolling With Slipping
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2025
Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface. An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
14:16
Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
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Cited by 32 •
2009
This report provides a visual depiction of parallel-plate flow chamber analysis for studying leukocyte endothelial interactions under physiologic shear stress. This method is particularly useful for investigating the role of endothelial (E)-selectin and leukocyte E-selectin ligands that trigger leukocyte rolling on endothelial cell surfaces.
01:21
Rolling Resistance
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2023
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures. For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
FAQs
Its placement directly above the cutting edge provides immediate support as the tissue section emerges from the paraffin block. That support counteracts mechanical forces acting on the very thin section, helping it remain flatter instead of curling or folding. The resulting ribbon is easier to handle and more likely to retain a continuous arrangement of tissue structures.
Very thin sections are especially vulnerable to distortion while they leave the cutting edge. Their limited structural strength allows compression, curling, or folding to interfere with the intended shape. By supporting the section at this critical point, the plate helps reduce these effects and promotes more consistent sections for later transfer, staining, and microscopic examination.
The accessory primarily helps limit curling, folding, and compression in sections cut from paraffin-embedded specimens. These defects can make a section less intact and can disrupt the visible arrangement of tissue architecture. Reducing them produces smoother ribbons, giving the microscopist a more reliable specimen for observing biological structures.
The key difference is that the plate supports each section immediately as it emerges, rather than allowing the thin material to move unsupported after cutting. This added contact helps control distortion caused by cutting forces. In practice, the supported sections are more likely to form smooth, intact ribbons that can be transferred efficiently to slides.
The plate should be positioned directly above the cutting edge, where it can contact or support the section as the section emerges from the paraffin-embedded specimen. This location is central to its function because support must occur at the moment cutting forces affect the thin tissue layer. Correct positioning therefore contributes to flatter, more continuous ribbons.
Smoother and more intact ribbons are easier to transfer onto microscope slides, which supports subsequent staining and microscopic examination. Better-preserved sections also maintain tissue architecture more effectively, helping observations reflect the biological organization of the specimen. In biology research, this consistency can contribute to more reliable interpretation of structures seen in histological preparations.