Collagen Remodeling
Collagen Remodeling - Related Videos
07:03
Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Cited by 18 •
2014
This procedure demonstrates in vivo near IR fluorescence imaging of collagen remodeling activities in mice as well as ex vivo staining of collagens in tissue sections using caged collagen mimetic peptides that can be photo-triggered to hybridize with denatured collagen strands.
02:54
Nucleosome Remodeling
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2020
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure. Nucleosome remodeling complex Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
09:28
Fabrication of Micro-tissues using Modules of Collagen Gel Containing Cells
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Cited by 9 •
2010
Creation of micro-tissues using cylindrical collagen gels, called modules, that contain embedded cells and which surface is coated with endothelial cells.
07:31
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
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Cited by 26 •
2016
A rat model of abdominal aortic constriction that induces cardiac hypertrophy and remodeling is described. An efficient, highly-reproducible, and minimally-invasive method is used to provide a simple yet useful platform for research in myocardial hypertrophy and dysfunction.
FAQs
Tissue strength depends on a regulated balance between collagen deposition and collagen removal. Fibroblasts and other cells add newly produced collagen, while matrix metalloproteinases and related enzymes cleave existing fibers. Reorganization of the extracellular matrix then permits structural adaptation and repair without abandoning the tissue framework over time.
The balance is shaped by mechanical forces, inflammatory signals, and tissue-specific cues. These inputs influence how actively cells produce collagen and how strongly enzymes cleave the existing matrix. Because the signals differ among tissues and biological situations, the same remodeling machinery can support maintenance, repair, or maladaptive structural change over time.
Uncontrolled or poorly coordinated activity can shift matrix turnover away from balanced maintenance. The resulting changes are associated with fibrosis, impaired healing, or tumor progression, rather than effective adaptation and repair. This distinction matters because remodeling is not inherently beneficial or harmful; its biological effect depends on regulation, timing, and tissue context.
An analysis can follow the linked processes described for the extracellular matrix: collagen production by fibroblasts and other cells, enzymatic cleavage of existing fibers, fiber reorganization, and the surrounding mechanical or inflammatory cues. Relating these dynamics to tissue strength, repair, or disease-associated change helps reveal whether remodeling supports normal function or becomes dysregulated.
It is relevant to wound healing, development, and ordinary tissue maintenance, where matrix structure must respond to changing biological demands. In each setting, studying collagen dynamics helps connect cellular activity with tissue-level organization and mechanics. The same subject therefore links basic biology of adaptation with questions about how tissues repair themselves.
Mapping how collagen is produced, cleaved, and reorganized can identify biological processes that influence tissue repair and disease. This knowledge may help researchers recognize potential intervention targets for regenerative medicine, fibrosis, impaired healing, or tumor progression. The value lies in connecting matrix dynamics to outcomes, rather than treating collagen abundance alone as the complete explanation.