Colonoscopic Guided Biopsy
Colonoscopic Guided Biopsy - Related Videos
03:39
Colonoscopic Guided Pinch Biopsy in a Mouse Model: A Technique to Visualize and Extract Tissue Samples from Mouse Colon
0 Views •
2025
This video demonstrates the protocol for performing colonoscope-guided pinch biopsy in the mouse. This technique helps visually analyze the colon lumen and collect tissue samples for detailed studies.
02:48
Colonoscopic Guided Murine Wound Model: A Method to Isolate Biopsy Induced Wound Bed from Colon to Understand the Healing Process
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2025
In this video, we describe a procedure to isolate the colonoscopic-induced wound bed at an appropriate time point for detailed molecular analysis. This analysis helps to understand the wound healing process in inflammatory conditions of the GI tract.
08:52
Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
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2021
Here, we provide a detailed description of the procedure to induce colonoscopic-guided pinch biopsies in mice and track wound closure in real time. Additionally, methods for the preparation of tissues for histological, immunohistochemical and molecular analyses of the wound bed are provided.
04:37
Sampling Prostate Cancer Tissue for Biobanking: An MRI-guided Targeted Technique to Remove Biopsy Punches from Fresh Tumor Tissue
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2023
This video demonstrates an MRI data-based technique to target specific tumor-containing regions in prostate tissue for sampling. The collected biopsy specimens can be either stored for biobanking purposes or used for subsequent downstream analysis.
10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Cited by 7 •
2014
Substernal thyroid lesions are common, and need to be differentiated from malignancy. Obtaining percutaneous fine needle biopsy is not possible due to its retrosternal location. This article proposes a protocol for biopsy of substernal thyroid lesions using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA).
FAQs
Direct visual guidance allows the operator to align tissue collection with an abnormal or suspicious area observed on the intestinal surface. This connection between the visible lesion and the removed specimen helps pathology findings correspond to a specific site in the colon, supporting more accurate interpretation of local tissue changes rather than relying on an unspecified sample.
The working channel provides a passage through which biopsy forceps can reach the selected area while the colonoscope continues to transmit images. This arrangement coordinates observation and sampling within the same procedure. Because the forceps remove small specimens under visual control, the collected tissue can be linked to the appearance of the lining that prompted examination.
Microscopic analysis can evaluate tissue for inflammation, infection, precancerous changes, or malignancy. These findings reveal changes that may not be distinguishable from surface appearance alone. Examining cellular and tissue structure therefore extends the biological information obtained during colonoscopy and helps classify the process affecting the colonic lining.
Correlating surface appearance with tissue structure connects an observed abnormality to the underlying disease process. The colonoscope supplies visual information, whereas pathology examines the specimen microscopically. Together, these perspectives help relate biological changes in tissue organization to conditions such as inflammation, infection, precancerous transformation, or malignancy.
The procedure begins with image transmission from a flexible colonoscope as the intestinal surface is examined. When an abnormal or suspicious area is identified, biopsy forceps pass through the instrument’s working channel and remove a small tissue specimen. The sample is then available for microscopic examination by pathologists, who assess its structural and disease-related features.
This approach is useful when an area of the colonic lining appears abnormal or suspicious during colonoscopy and requires tissue-level evaluation. It can support investigation of inflammation, infection, precancerous changes, and malignancy. In biology and medicine, the resulting specimen provides material for connecting visible findings with microscopic disease processes.
Pathology results can provide evidence for diagnosing and classifying a disease by identifying characteristic tissue changes. That classification gives clinicians a stronger basis for planning treatment than visual inspection alone. The method also reduces the need for more invasive tissue collection procedures, making tissue-based evaluation possible through a minimally invasive route.