Electroencephalogram

An electroencephalogram (EEG) is a noninvasive recording of the brain’s electrical activity, used to study neural function and detect abnormal patterns in biology and medicine. During EEG, electrodes placed on the scalp detect voltage changes produced by the synchronized activity of large populations of cortical neurons; amplifiers record these signals over time as waveforms. Researchers and clinicians use EEG to investigate sleep, sensory processing, cognition, and brain development, while also supporting the evaluation of seizures and other neurological conditions. Because it provides millisecond-level temporal resolution, EEG complements imaging methods that more precisely localize activity but capture changes more slowly.

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JoVE EoE - Neurophysiology

Analyzing Sleep Behavior in Mice through Electroencephalogram and Electromyogram Recordings

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2025

This video demonstrates a protocol for implanting an electroencephalogram (EEG) and electromyogram (EMG) electrode assembly in an anesthetized mouse. The process involves securing the mouse on a stereotaxic frame, making a midline incision in the skull, drilling holes for the electrodes, and fixing the electrode unit for signal recording. After recovery, the mouse's sleep-wake behavior is analyzed using the recorded signals.

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram

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2025

This protocol establishes a practical approach for combining HD-tACS with EEG to examine stimulation effects on neural oscillations during cognitive tasks, using theta-frequency stimulation in working memory as an exemplar.

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

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Cited by 2 •

2019

Standard EEG analysis techniques offer limited insight into nervous system function. Deriving statistical models of cortical connectivity offers far greater ability to investigate underlying network dynamics. Improved functional assessment opens new possibilities for diagnosis, prognostication, and outcome prediction in nervous system diseases.

Implantation of Electroencephalogram and Electrocardiogram Telemetry Devices in Neonatal Rabbit Kits

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Cited by 1 •

2025

Mechanisms of sudden unexpected death in epilepsy (SUDEP) are poorly understood and challenging to translate from current models. Transgenic rabbits may offer insights into these mechanisms. We describe a method for long-term, continuous electroencephalography and electrocardiography recordings in transgenic rabbit kits to evaluate serious events that may lead to death.

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

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Cited by 8 •

2020

This manuscript describes a method for continuous video EEG recordings using multiple depth electrodes in neonatal mice undergoing hypoxia-ischemia.

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