Gold-plated Needles
Gold-plated Needles - Related Videos
09:51
Intraosseous Needle Placement
0 Views •
2023
Source: Julianna Jung, MD, FACEP, Associate Professor of Emergency Medicine, The Johns Hopkins University School of Medicine, Maryland, USA For unstable patients requiring urgent administration of medications, fluids, or blood products, establishing vascular access quickly is essential. However, there are many factors that can complicate placement of a peripheral intravenous cannula (PIV), and it is extremely common for PIV attempts to fail. PIV placement may be technically challenging in small...
09:31
Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
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Cited by 9 •
2015
This protocol outlines how to use the transient heating associated with the optical absorption of gold nanorods to stimulate differentiation and intracellular calcium activity in neuronal cells. These results potentially open up new applications in neural prostheses and fundamental studies in neuroscience.
08:21
Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
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Cited by 1 •
2017
We demonstrate the fabrication of periodic gold nanocup arrays using colloidal lithographic techniques and discuss the importance of nanoplasmonic films.
08:25
Needle Thoracostomy
0 Views •
2015
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA A tension pneumothorax is a life-threatening situation in which excess air is introduced into the pleural space surrounding the lung, either through trauma to the chest cavity or as a spontaneous leak of air from the lung itself. Air trapped within the pleural space causes separation of the lung from the chest wall, disrupting normal breathing mechanisms. Pneumothorax may be small without...
08:55
Hydroquinone Based Synthesis of Gold Nanorods
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Cited by 11 •
2016
This paper describes a protocol for the synthesis of gold nanorods, based on the use of hydroquinone as reducing agent, plus the different mechanisms for controlling their size and aspect ratio.
FAQs
The gold coating serves two linked functions at the probe interface: it provides a conductive path for electrical signals and shields much of the underlying needle from corrosion. This combination helps preserve signal transmission while maintaining the probe during contact with biological material. Consequently, measurements or stimulation can be performed under controlled conditions with less concern about degradation of the underlying needle.
Surface compatibility matters because a needle intended to contact cells, tissues, or biofluids must function without an unsuitable interface disrupting the experiment. The relatively inert gold surface supports that interaction, while chemical stability helps the probe remain reliable. This is especially relevant when the same type of probe is used across different biological sample environments.
Sharp geometry allows these probes to be positioned precisely for intracellular recording or stimulation, while the conductive gold surface carries electrical signals at the biological interface. Combining these features lets researchers relate electrical activity or applied stimulation to a defined cellular location. The approach is therefore useful when spatially targeted electrophysiological interaction is important.
Use requires controlled positioning of the sharp probe and a clearly defined biological interaction, such as recording, stimulation, or microinjection. Cells, tissues, and biofluids present different experimental contexts, so the probe’s conductive and chemically stable surface must be considered alongside the intended measurement or manipulation. These controls support precise contact and more reliable electrical outcomes.
Gold-plated needles can support several complementary biological applications: intracellular recording, stimulation, and microinjection, as well as tissue-interfacing methods requiring precise positioning and dependable signal transmission. They are also relevant to cellular electrophysiology, where researchers examine or influence electrical behavior at defined locations. The appropriate use depends on whether the experiment prioritizes measurement, stimulation, delivery, or interface development.
Their conductive, relatively inert surface supports biosensor development by providing a biologically compatible interface that can transmit electrical signals. The same properties support minimally invasive research tools in which a sharp probe must interact with biological material under controlled conditions. This makes them relevant both to sensing designs and to tissue-interfacing studies.