Human Genetics

Human genetics is the study of how genetic information is organized, inherited, and expressed in people, and how variation influences health and biological traits. It examines DNA, genes, chromosomes, and genomes, including how mutations, recombination, and patterns of inheritance transmit or alter genetic information across generations. Research in human genetics supports the identification of disease-associated variants, genetic testing, diagnosis, and risk assessment, while informing genetic counseling and personalized approaches to treatment. It also provides a foundation for studying human evolution, population diversity, and the ethical implications of genomic research.

Human Genetics - Related Videos

Education

JoVE Core - Introduction to Psychology

Human Genetics

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2024

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape. The complex relationship between genetics and psychology is observable through common biological components such...

Research

JoVE EoE - Skin Cancer

Genetic Modification of Primary Human Keratinocytes: A Method for Genetically Manipulating Keratinocytes Using Recombinant Retroviruses

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2023

This video describes a detailed protocol for producing genetically modified primary human keratinocytes recombinant retrovirus. This method can be used to manipulate gene expression in keratinocytes.

Generation and Genetic Manipulation of Human Cervical Organoids

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2026

We present a detailed protocol to establish and genetically manipulate human cervical organoids.

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

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Cited by 2 •

2010

Genetic studies in yeast can be employed to investigate the molecular and cellular functions of human genes in cellular DNA metabolism. Methods are described for the genetic characterization of the human WRN gene product defective in the premature aging disorder Werner syndrome in functionally conserved pathways using yeast as a tractable model system.

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

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Cited by 22 •

2015

The goal of this paper is to provide a comprehensive and detailed protocol on how to generate genetically modified human organotypic skin from epidermal keratinocytes and devitalized human dermis.

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