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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Article DOI: 10.3791/1639 • 14:10 min • March 18th, 2010
March 18th, 2010 •
1, 1
1Laboratory of Molecular Gerontology, National Institute on Aging, NIH

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Summary
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Genetic studies in yeast can be employed to investigate the molecular and cellular functions of human genes in cellular DNA metabolism. Methods are described for the genetic characterization of the human WRN gene product defective in the premature aging disorder Werner syndrome in functionally conserved pathways using yeast as a tractable model system.

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Genetic Studies Human DNA Repair Proteins Yeast Model System Mammalian Systems Model Genetic Systems Lower Eukaryotes Werner Syndrome Helicase-nuclease (WRN) Nucleic Acid Metabolism Cellular Phenotypes Genetic Mutant Backgrounds Catalytic Activities Protein Interactions WRN Gene DNA Plasmids Regulatory Plasmid Element Yeast Mutant Background Genomic Stability
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