Hydrocephalus

Hydrocephalus is a neurological disorder in which cerebrospinal fluid accumulates abnormally within the brain’s ventricles, potentially affecting brain structure and function. It develops when cerebrospinal fluid flow or absorption is disrupted, causing ventricular enlargement and, in some cases, increased pressure on surrounding neural tissue. In biology and medicine, studying hydrocephalus helps researchers understand cerebrospinal fluid circulation, ventricular development, and the effects of pressure on the nervous system. Clinical evaluation and imaging support diagnosis, while treatments that redirect or drain excess fluid can relieve pressure and reduce neurological complications. Research continues to clarify its diverse causes and improve patient care.

Hydrocephalus - Related Videos

Research

JoVE Journal - Neuroscience

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

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Cited by 3 •

2025

Posthemorrhagic hydrocephalus of prematurity (PHHP) can be modeled in neonatal rats by combining chorioamnionitis and intraventricular hemorrhage. The combination of these prenatal and postnatal events accurately recapitulates the clinical hallmarks of PHHP, including macrocephaly, ventriculomegaly, and elevated intracranial pressure, through the lifespan.

Neuronavigation and Laparoscopy Guided Ventriculoperitoneal Shunt Insertion for the Treatment of Hydrocephalus

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Cited by 4 •

2022

Patient outcomes of ventriculoperitoneal (VP) shunt surgery, the mainstay treatment for hydrocephalus in adults, are poor due to high shunt failure rates. We present intraoperative footage of VP shunt insertion using neuronavigation and laparoscopy guidance, with the goal to reduce the risks of proximal and distal shunt catheter failures, respectively.

Manual Drainage of the Zebrafish Embryonic Brain Ventricles

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Cited by 9 •

2012

We present a method to collect cerebrospinal fluid (CSF) and to create a system which lacks CSF within the embryonic zebrafish brain ventricular system. This allows for further examination of CSF composition and its requirement during embryonic brain development.

Live Imaging of the Ependymal Cilia in the Lateral Ventricles of the Mouse Brain

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Cited by 12 •

2015

Using high-resolution differential interference contrast (DIC) microscopy, an ex vivo observation of the beating of motile ependymal cilia located within the mouse brain ventricles is demonstrated by live-imaging. The technique allows a recording of the unique ciliary beating frequency and beating angle as well as their intracellular calcium oscillation pacing properties.

Research

JoVE Journal - Behavior
Free Sample

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)

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Cited by 4 •

2015

Prolonged and comprehensive monitoring of mice in a home-cage environment provides a deeper understanding of aberrant behavior in murine models of brain diseases. This paper describes the Integrated Behavioral Station (INBEST) as the key component of contemporary behavioral analysis.

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