Liver Gallbladder

The liver and gallbladder are accessory organs of the digestive system that process nutrients, regulate metabolism, and support the digestion of fats. The liver continuously produces bile, while the gallbladder stores and concentrates it before releasing it into the small intestine in response to a meal; bile salts then emulsify dietary lipids, helping digestive enzymes break them down. Together, these organs also contribute to detoxification, protein production, nutrient storage, and waste excretion. Studying liver and gallbladder function provides essential insight into digestion, metabolic regulation, and disorders such as gallstones, hepatitis, and impaired bile flow.

Liver Gallbladder - Related Videos

Education

JoVE Core - Anatomy and Physiology

Diseases of the Liver and Gallbladder

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2024

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease. Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

Gallbladder

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2024

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion. The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...

Research

JoVE Journal - Biology
Free Sample

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

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Cited by 14 •

2011

The study of liver sinusoidal endothelial cells (SECs) must be performed with primary cells obtained from the animal as no cell lines exist. This method relies on liver digestion and differential centrifugation for SEC purification for subsequent culturing and experimentation.

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels

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2025

Here, we present a protocol to establish a long-term liver cold storage and transplantation model in Daurian ground squirrel (DGS), which has been technically challenging in standard rodent models.

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

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Cited by 14 •

2017

Here we describe a common method to induce chronic liver injury in mice by feeding of a choline-deficient and ethionine-supplemented (CDE) diet. We demonstrate health monitoring, liver perfusion, isolation, and preservation. A time course of six weeks can inform about liver injury, pathohistology, fibrosis, inflammatory, and liver progenitor cell responses.

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