Muscle Restoration

Muscle restoration is the biological recovery of muscle structure and function after injury, disuse, disease, or intense exercise. It depends on coordinated inflammation, removal of damaged tissue, activation of muscle stem cells called satellite cells, and the formation and remodeling of muscle fibers; protein synthesis then supports growth and repair. In biology and medicine, studying these processes helps explain how skeletal muscle adapts to physical demands and why recovery may decline with age or chronic illness. Research on muscle restoration informs rehabilitation strategies, regenerative therapies, exercise programming, and approaches to improving mobility and quality of life after muscle damage.

Muscle Restoration - Related Videos

Education

JoVE Core - Nursing

Restorative Care

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2023

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...

Research

JoVE EoE - Neurotherapeutics

Muscle Grafting as a Surgical Strategy for Restoring Blood Flow to the Mouse Brain After Stroke

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2025

Source: Paro, M. R., et.al. A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice. J. Vis. Exp. (2022).This video demonstrates a surgical procedure to graft a vascularized muscle onto the brain surface following transient middle cerebral artery occlusion. The graft promotes new blood vessel formation in the ischemic region, enhancing oxygen and nutrient supply. Over time, the integrated muscle supports neuronal survival and aids in...

CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors

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Cited by 6 •

2019

Here, we present a Cas9-based exon23 deletion protocol to restore dystrophin expression in iPSC from Dmdmdx mouse-derived skin fibroblasts and directly differentiate iPSCs into myogenic progenitor cells (MPC) using the Tet-on MyoD activation system.

Direct Reconnection of Cervical Nerves to Restore Forelimb Mobility in a Mouse

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2025

Source: Gao, Z., et al. A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery. J. Vis. Exp. (2021).This video demonstrates restoring forelimb movement in a mouse via direct cervical nerve reconnection. It begins with a mouse with a paralyzed right forelimb due to a transected right C7 nerve at its nerve root. The left C7 nerve is severed, guided to the right via the prespinal route, and sutured with the right C7 nerve. The surgical site is then cleaned...

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

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Cited by 1 •

2025

Here, we evaluated the impact of various polishing methods on the color stability of compomer and composite resin restorations used in anterior restorations within pediatric dentistry. This study highlights the significance of selecting appropriate polishing methods to enhance the color stability of compomer and composite resin restorations in pediatric dentistry.

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