P-cadherin
P-cadherin - Related Videos
01:25
Structure of Cadherins
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2023
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
01:19
Cadherins in Tissue Organization
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2023
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues. Cell Sorting During Development Cell sorting plays an...
04:42
Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic Flies
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2016
Herein we describe a procedure to capture live images of Drosophila gastrulation. This has enabled us to better understand the apical constriction involved in early development and further analyze mechanisms governing cellular movements during tissue structure modification.
06:07
RNA Isolation from Mouse Ocular Lens Epithelium and Fiber Cell Bulk Masses
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2025
This protocol details the separation of the mouse ocular lens epithelium and fiber cell bulk mass, followed by RNA isolation and qPCR analysis. This method allows for separating lens cell compartments for a more detailed analysis of the transcriptome and biological processes in epithelial cells vs. differentiated fiber cells.
05:54
Spinal Cord Transection In Xenopus laevis Tadpoles
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Cited by 5 •
2021
Xenopus laevis tadpole spinal cord transection is a relevant injury method to study spinal cord injury and regeneration by making a transverse cut that completely severs the spinal cord at the thoracic level.
FAQs
Calcium supports the adhesive conformation of P-cadherin, allowing junctions to remain stable between neighboring epithelial cells. When this calcium-dependent support changes, the protein’s ability to maintain organized cell contacts may be affected. This relationship is important for understanding how epithelial tissues preserve continuous architecture and form effective barriers during development and tissue maintenance.
Catenin proteins provide the molecular connection between P-cadherin at the cell membrane and the actin cytoskeleton inside the cell. This linkage converts cell-cell adhesion into a structurally integrated system rather than an isolated membrane interaction. Its organization helps epithelial cells maintain tissue shape, coordinated architecture, and stable adherens junctions.
Changes in P-cadherin expression can modify how cells remain attached and how they organize relative to one another. The resulting effects may include altered cell migration and changes in tissue architecture. Examining these shifts helps connect molecular regulation at adherens junctions with larger biological outcomes, including disrupted epithelial organization and abnormal tissue structure.
P-cadherin-mediated contacts contribute to the spatial organization of epithelial cells, which supports cell sorting and tissue polarity. These organized arrangements also help establish epithelial barriers. Studying the protein therefore links a junctional adhesion mechanism to tissue-level properties, revealing how cells acquire appropriate positions and maintain coordinated epithelial structure during development.
A useful investigation considers P-cadherin expression, its location at adherens junctions, its connection through catenins to actin, and associated changes in cell behavior. Researchers can relate these molecular features to migration, polarity, barrier formation, and tissue architecture. This framework helps explain how epithelial organization is maintained or becomes altered.
P-cadherin research provides a way to examine how disrupted cell adhesion may influence tissue architecture and invasion during cancer progression. Comparing adhesion-related changes with altered cell migration can clarify how epithelial organization becomes dysregulated. The protein is therefore relevant to biomedical studies of cancers in which loss of coordinated tissue structure accompanies more invasive behavior.