Renal Capsule
Renal Capsule - Related Videos
03:00
Extracting Intact Kidney from Mouse: A Technique to Obtain Kidney Without Renal Capsule from Murine Models
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2023
In this video, we describe the procedure for kidney extraction from the retroperitoneal space of the mouse. The extracted kidney can further be microdissected to obtain an intact kidney without a renal capsule and the surrounding fat layer.
04:12
Renal Capsule Tumor Xenografting: A Technique to Generate an Experimental Animal Model to Evaluate Prostate Carcinogenesis
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2023
In this video, we demonstrate the implantation of human-derived prostate cancer tissue grafts into the renal capsule of an immunocompromised recipient mouse. This technique can be used to assess tumor progression and develop novel therapeutic strategies.
08:38
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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Cited by 13 •
2013
We describe the manufacture of compressed hormone pellets, as well as subcutaneous surgical implantation into mice. This strategy can be combined with the growth of cell and tissue xenografts under the renal capsule of athymic nude mice to evaluate hormonal carcinogenesis and regulation of benign prostate growth.
06:31
Murine Bilateral Renal Lymphadenectomy
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2025
This protocol describes a survival procedure for safe and well-tolerated murine bilateral renal lymphadenectomy.
03:21
Murine Renal Cell Isolation: A Technique to Isolate and Generate Primary Culture of Renal Tubular Epithelial Cells
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2023
In this video, we demonstrate the steps to isolate and purify renal tubular epithelial cells for a wide range of molecular biology and cell culture studies.
FAQs
Dense collagen fibers give the capsule a firm, mechanically supportive character. This organization helps the kidney resist deformation and contributes to preservation of its overall shape while surrounding the renal cortex. In anatomical study, the capsule therefore provides evidence of how connective tissue can stabilize a highly organized internal organ.
The capsule marks the external boundary of the kidney and helps distinguish the organ from adjacent perirenal fat and other surrounding tissues. Following this boundary also improves orientation when relating the outer cortex to the deeper medulla. These relationships are useful when interpreting gross specimens or describing how kidney regions are arranged.
Alterations in the capsule’s appearance or attachment may provide context about the condition of the kidney and its interfaces with nearby tissues. They can be considered during studies of kidney injury, inflammation, or tumors, as well as in anatomical specimens. Such observations do not stand alone, but help organize the description of abnormal or preserved tissue.
Examination begins by observing the kidney’s outer surface, noting the capsule’s visible appearance and how closely it remains attached to the organ. The investigator can then relate those findings to the cortex, surrounding perirenal fat, and any visible irregularities. This approach preserves the capsule’s value as a boundary marker while documenting specimen organization.
A useful description should include the capsule’s overall appearance, its relationship to the renal surface, and the character of its attachment to underlying or neighboring tissues. Observations can then be compared with the visible organization of the cortex and medulla. Recording these features supports consistent anatomical documentation and may highlight changes relevant to disease studies.
In these research contexts, investigators can assess the capsule as part of the kidney’s external anatomy rather than viewing the internal regions in isolation. Its appearance and attachment may help describe how abnormal conditions relate to the organ boundary and surrounding tissues. This adds structural context to observations of affected kidneys or preserved anatomical specimens.