Renal Orthotopic Transplantation
Renal Orthotopic Transplantation - Related Videos
18:25
Orthotopic Liver Transplantation in Rats
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Cited by 31 •
2012
We present an easy-to-establish revision of the classical two-cuff technique for orthotopic liver transplantation in rat.
09:16
Orthotopic Small Bowel Transplantation in Rats
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Cited by 4 •
2012
Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.
18:48
Murine Renal Transplantation Procedure
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Cited by 20 •
2009
Renal transplantation in mice is a technically challenging procedure that requires careful post-operative care and treatment for success.
07:15
Orthotopic Hind Limb Transplantation in the Mouse
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Cited by 24 •
2016
This novel model for orthotopic hind limb transplantation in the mouse, applying a non-suture cuff technique for super-microvascular anastomosis, provides a powerful tool for in vivo mechanistic immunological research related to vascularized composite allotransplantation (VCA).
06:59
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
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Cited by 2 •
2022
The rat orthotopic renal transplantation model contributes to investigating the mechanism of renal allograft rejection. The current model increases the recipients' survival without interference with blood supply and venous reflux of the lower body using an end-to-end anastomosis of kidney implantation and an end-to-side "tunnel" method of ureter-bladder anastomosis.
FAQs
Successful graft function requires more than positioning the donor organ. Surgeons connect the graft to the recipient’s renal blood vessels so blood can reach the transplanted kidney, then join its ureter to an appropriate urinary pathway. These connections permit filtration, urine production, and drainage through anatomically appropriate routes.
Selection centers on anatomy rather than a different goal for renal replacement. Orthotopic placement may be valuable when the recipient’s pelvic vessels cannot support the usual arrangement or when urinary anatomy makes pelvic implantation unsuitable. Evaluating these constraints helps match graft location with available vascular and urinary pathways.
Immunosuppressive therapy is used to limit immune-mediated rejection, which can threaten graft function after transplantation. In this context, treatment is part of the biological management of organ compatibility rather than a substitute for surgical reconstruction. Its relevance extends to studies of graft survival and long-term transplant management.
Unlike the more common heterotopic approach, renal orthotopic transplantation places the graft in the native renal fossa rather than the pelvis. The distinction matters when pelvic vessels or urinary anatomy are unsuitable, making the native renal region a more appropriate site for vascular and ureteral reconstruction. Thus, location is determined by recipient anatomy.
Beyond its clinical role, the procedure provides a model for investigating transplantation biology. Researchers can examine how organ compatibility, immune-mediated rejection, and immunosuppressive therapy relate to graft survival. It also supports study of long-term management in kidney failure, linking surgical anatomy with biological and clinical outcomes.
Within biology, the approach connects organ replacement with questions about renal function, immune response, and graft survival. Its use in selected kidney-failure cases also creates a context for examining how anatomically appropriate connections support filtration, urine production, and drainage while clinicians address long-term transplant management.