Self-renewal
Self-renewal - Related Videos
05:58
The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
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Cited by 7 •
2009
SC1 functions through dual inhibition of Ras- GAP and ERK1. We tested the function of SC1 in supporting mouse ES cell self-renewal in the absence of LIF and showed that SC1 is able to maintain self-renewal of mouse ES cell cultures.
01:23
Tissue Renewal without Stem Cells
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2023
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis. However, failure of such a system...
01:23
Renewal of Intestinal Stem Cells
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2023
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
09:55
Surface Renewal: An Advanced Micrometeorological Method for Measuring and Processing Field-Scale Energy Flux Density Data
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Cited by 21 •
2013
Surface renewal is a micrometeorological method that is being used increasingly to determine energy fluxes, but its technical complexity makes it inaccessible to a broad audience. We describe the steps needed to set up and calibrate a surface renewal field station, to acquire and process data, and to correctly interpret results.
01:12
Renewal of Skin Epidermal Stem Cells
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2023
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
FAQs
Self-renewal is controlled by an interaction between intrinsic cellular programs and signals from outside the cell. Intrinsic programs help establish a cell’s potential, while external signals influence whether that potential is maintained or redirected. Their combined effects help coordinate renewal with differentiation, making the balance responsive to developmental or tissue-specific conditions.
Symmetric and asymmetric divisions distribute renewal and differentiation potential in different ways. Symmetric divisions can expand a population or produce cells with similar fates, whereas asymmetric divisions can preserve a renewing cell while generating a cell that begins differentiation. This distinction allows cell populations to increase when needed while retaining a reserve for continued tissue maintenance.
A functional cell population must replace or replenish cells without losing the capacity to generate specialized descendants. The balance between renewal and differentiation supports embryonic development, tissue homeostasis, and repair. If renewal is insufficient, functional reserves may decline; if it becomes poorly regulated, abnormal expansion can occur, linking disrupted control to disease-associated growth.
Disruption of the controls governing self-renewal can alter the normal relationship between continued cell production and differentiation. When cells retain renewal capacity inappropriately or expand without balanced differentiation, populations may grow abnormally. This connection makes self-renewal relevant to cancer biology, particularly when researchers examine disease-associated cell populations and the mechanisms that sustain them.
Researchers can use self-renewal as a framework for examining cell fate decisions: how cells preserve defining properties, when they begin differentiation, and how intrinsic programs interact with external signals. These questions connect single-cell behavior with tissue-level maintenance. The resulting knowledge helps explain how cell reserves are established, sustained, and mobilized during development or repair.
Understanding the controls that balance renewal and differentiation can guide regenerative medicine and the development of stem-cell-based models. Such research helps clarify how to maintain useful cell populations while preserving their capacity to produce appropriate descendants. It also provides a biological basis for studying tissue repair and for developing strategies directed at disease-associated populations.