Tolerance Induction
Tolerance Induction - Related Videos
11:33
Inductance
0 Views •
2023
Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN This experiment will use inductive coils to demonstrate the concept of inductor and inductance. Magnetic induction will be demonstrated using a rod magnet inserted into or extracted away from the core of a coil to induce a transient electromotive force (emf) voltage in the coil, measured by a voltmeter. This experiment will also demonstrate the mutual inductance between...
01:17
Salinity Tolerance of Alishewanella Species Isolated from Seawall Muddy Water
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2025
Begin with a culture of Alishewanella, a Gram-negative, salt-tolerant bacterium.Next, streak the culture onto agar plates containing increasing concentrations of sodium chloride to simulate varying levels of saline stress.Overlay each plate with a layer of unsolidified medium to prevent oxygen diffusion and maintain the culture in an oxygen-limited environment.Seal and incubate the plates at an optimum temperature to support bacterial growth.During incubation, the bacterium exhibits varying...
07:46
Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
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Cited by 30 •
2013
There is accumulating evidence, that ischemic preconditioning (PC) – a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We established bilateral common carotid artery occlusion (BCCAO) as a preconditioning stimulus to induce early ischemic tolerance (IT) to transient focal cerebral ischemia (induced by middle cerebral artery occlusion, MCAO) in C57Bl6/J mice.
10:27
VFD-fed AC Induction Machine
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. Variable frequency drives (VFDs) are a type of adjustable speed drive, which are becoming standard equipment to power most AC induction motors. VFDs are common in industrial and automation applications and typically provide robust control of the motor in speed, torque, or position modes. The VFDs tested and simulated in this experiment focus on speed and open-loop control with constant voltage to...
08:22
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
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Cited by 52 •
2017
This manuscript provides an updated remote supervision protocol that enables participation in transcranial direct current stimulation (tDCS) clinical trials while receiving treatment sessions from home. The protocol has been successfully piloted in both patients with multiple sclerosis and Parkinson's disease.
FAQs
Central tolerance acts during lymphocyte development, removing cells that strongly recognize self-antigens before they mature. Peripheral tolerance provides additional control after these cells enter the immune system. A mature lymphocyte may become anergic, meaning functionally unresponsive, or may be suppressed by regulatory T cells. Together, these safeguards create layered protection against inappropriate immune responses.
The strength of recognition helps determine whether a developing lymphocyte is retained or eliminated. Cells that strongly recognize self-antigens are candidates for deletion, reducing the likelihood that they will participate in harmful self-directed responses. This selection process supports immune discrimination by limiting dangerous cells while preserving the broader capacity to respond to pathogens.
Anergy limits the activity of mature lymphocytes even when they encounter a relevant antigen, preventing activation from progressing normally. Regulatory T cells provide a separate suppressive mechanism that restrains immune responses. Because these processes act after lymphocyte development, they extend tolerance beyond central deletion and help control cells that remain in the mature immune-cell population.
Tolerance induction aims to establish unresponsiveness toward specific antigens while maintaining responses to harmful pathogens. Broad immune suppression, by contrast, would reduce immune activity more generally. This distinction makes antigen-specific regulation especially important in biology and medicine, because the desired outcome is control of an inappropriate response without broadly weakening host defense.
In transplantation research, tolerance induction is examined as a way to regulate immune recognition of transplanted organs. The goal is to reduce damaging responses directed at transplant-associated antigens while preserving protection against pathogens. This application connects central deletion, peripheral anergy, and regulatory T-cell suppression to efforts to achieve more selective immune control.
Researchers study tolerance induction to determine whether immune responses associated with allergic reactions can be reduced through antigen-specific regulation. The relevant strategy is not simply to weaken immunity, but to promote unresponsiveness toward the triggering antigen. Understanding how mature cells become anergic or are restrained by regulatory T cells provides a biological framework for this therapeutic direction.
Tolerance-induction research helps explain how failures in self-tolerance may permit immune responses against the body's own antigens. By examining deletion during lymphocyte development and suppressive mechanisms in mature immune cells, researchers can identify biological points at which inappropriate responses might be controlled. These findings support the development of antigen-specific approaches rather than nonspecific immune weakening.