Otx1 Otx2
Otx1 Otx2 - Related Videos
07:00
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Cited by 8 •
2019
Homeobox genes are regulatory genes often associated with tumors in the adult organisms. We investigated their comparative expression by immunohistochemical and real-time PCR analysis, in normal and inflammatory nasal mucosae and in sinonasal neoplasms in order to use them as possible diagnostic and therapeutic targets.
11:13
Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo
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Cited by 1 •
2016
In Xenopus embryos, cells from the roof of the blastocoel are pluripotent and can be programmed to generate various tissues. Here, we describe protocols to use amphibian blastocoel roof explants as an assay system to investigate key in vivo and in vitro features of early neural development.
12:45
Development of a Refined Protocol for Trans-scleral Subretinal Transplantation of Human Retinal Pigment Epithelial Cells into Rat Eyes
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Cited by 17 •
2017
Subretinal injection has been widely applied in preclinical studies of stem cell replacement therapy for age-related macular degeneration. In this visualized article, we describe a less risky, reproducible and precisely modified subretinal injection technique via the trans-scleral approach to deliver cells into rat eyes.
FAQs
The conserved homeodomain enables the encoded proteins to bind specific DNA sequences and influence transcription. Through this DNA-directed activity, OTX1 and OTX2 can regulate networks rather than isolated genes, affecting cell identity, proliferation, differentiation, and survival. This mechanism helps explain why abnormal activity may connect developmental gene-control programs with tumor-associated behavior.
Dysregulated activity can disturb the gene-expression networks that normally coordinate cell identity, proliferation, differentiation, and survival. When these processes become improperly controlled, cells may retain growth-promoting or survival-associated characteristics. In cancer research, examining OTX1 and OTX2 therefore helps investigators study how altered transcriptional regulation may contribute to tumor growth and maintenance.
OTX1 and OTX2 are investigated for possible roles in maintaining stem-like cell states and resisting differentiation. These features can preserve a less specialized cellular program instead of allowing cells to mature. Studying that relationship gives cancer researchers a way to connect developmental regulation with tumor maintenance and to examine why some malignant cells may remain difficult to differentiate.
A study can examine whether OTX1 or OTX2 expression or activity is altered and how that alteration relates to gene-regulatory networks and tumor-associated cellular properties. Researchers may focus on links with proliferation, survival, differentiation, cell identity, or stem-like states. This approach connects molecular regulation with observable features relevant to tumor biology.
Their altered expression or activity may provide measurable information about transcriptional states associated with tumor biology. Researchers can investigate whether these factors distinguish particular patterns of cell identity, proliferation, differentiation, survival, or stem-like behavior. Such findings could support biomarker discovery by linking molecular features to biologically relevant characteristics of tumors.
Because OTX1 and OTX2 can control gene-expression networks, studying their abnormal activity may identify regulatory processes that sustain tumor growth, maintenance, or resistance to differentiation. This knowledge can guide investigation of therapies aimed at abnormal transcriptional regulation rather than only downstream cellular effects. Their relevance is therefore both mechanistic and translational within cancer research.