Pancreatic Tumor Ablation
Pancreatic Tumor Ablation - Related Videos
03:50
Irreversible Electroporation: A Technique for Ablating Pancreatic Tumor in Mouse
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2023
This video describes the procedure for performing irreversible electroporation (IRE) for non-thermal ablation of pancreatic tumors in mice. Both subcutaneous (SQ) and orthotopic tumors can be successfully treated with IRE in a highly controlled setting, facilitating various studies post-procedure.
07:16
Thermal Ablation for the Treatment of Abdominal Tumors
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Cited by 19 •
2011
A thermal tumor ablation procedure is described. The entire procedure is detailed, including pretreatment planning and imaging studies, anesthesia, adjuvant techniques to facilitate a percutaneous approach, imaging guidance of the ablation device to the tumor, thermal treatment, post-treatment care and follow-up.
03:59
Orthotopic Homograft Tumor Transplantation: A Technique to Generate Pancreatic Tumor Mouse Models
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2023
The video explains a stepwise surgical method for orthotopic implantation of a tumor fragment from a cancerous donor to the pancreas of a non-cancerous recipient mice for development of pancreatic cancer. Orthotopically implanted PDAC could recapture the tissue microenvironment of human pancreatic cancers than conventional subcutaneous (SC) models more accurately.
05:11
Treatment of Middle-segment Pancreatic Benign Tumor Using Laparoscopic Central Pancreatectomy with End-to-end Pancreatic Duct Reconstruction
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2026
This article presents laparoscopic central pancreatectomy with pancreatic duct end-to-end anastomosis as an important surgical approach for middle-segment pancreatic benign and low-grade malignant tumors.
01:20
Laser Interstitial Thermal Therapy for Intracranial Tumor Ablation in a Human Patient
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2025
Begin with an anesthetized human patient with an exposed skull. The patient is diagnosed with an intracranial tumor.Drill into the exposed skull to create a hole, generating an access point.Using stereotactic guidance, insert a laser diffusing fiber or LDF along the predetermined path and secure it in place.Transfer the patient to an MRI scanner and connect the LDF to a laser source.Capture MRI images from multiple angles to visualize the fiber path and the tumor.This confirms the LDF’s...
FAQs
The mechanism depends on the energy modality selected. Heat, freezing, or electrical disruption can produce irreversible cellular injury in the treated tumor tissue. Because the applicator is placed within or near the target under image guidance, the approach is designed to focus the effect locally while aiming to preserve nearby healthy pancreatic and surrounding structures.
Image guidance supports two linked goals: locating the tumor and directing the applicator to an appropriate position within or near it. This matters because treatment precision is central to limiting injury to healthy structures. The technique therefore depends not only on the energy delivered, but also on accurate targeting and applicator placement.
Ablation provides a local approach to pancreatic cancer management, while systemic therapy represents a separate treatment strategy. The provided context identifies their combination as an ongoing research area rather than an established conclusion. Investigators are evaluating whether both approaches can be incorporated safely and effectively into multidisciplinary care.
An image-guided procedure begins by identifying the target and positioning an applicator within or near the pancreatic tumor. Clinicians then deliver the selected energy, which may use heat, freezing, or electrical disruption. The method determines the injury mechanism, while image guidance helps focus treatment on the intended tissue and supports the goal of sparing surrounding healthy structures.
Patient selection centers on clinical circumstances rather than tumor presence alone. Selected patients with unresectable or difficult-to-treat pancreatic tumors may be considered for ablation. The technique may support local disease control or symptom relief, and its role should be evaluated within multidisciplinary pancreatic cancer care rather than considered independently from the broader treatment plan.
Current research is examining more than whether tumor tissue can be destroyed. Key questions include safety, treatment precision, potential combination with systemic therapy, and how the technique fits into multidisciplinary care. These priorities reflect the need to understand both local treatment performance and its place in broader pancreatic cancer management.