Conjugate Acid

A conjugate acid is the species formed when a base accepts a proton, making it a central concept in Brønsted–Lowry acid–base chemistry. During proton transfer, the base gains H+ and becomes its conjugate acid, while the original acid loses H+ to form a conjugate base; these partners create conjugate acid–base pairs that interconvert in equilibrium. The relative strength of a conjugate acid reflects how readily it donates that proton, helping predict reaction direction and equilibrium position. Conjugate acids are important for understanding buffer capacity, calculating pH, interpreting aqueous reactions, and explaining proton-transfer mechanisms in biological and laboratory systems.

Conjugate Acid - Related Videos

Education

JoVE Core - Chemistry

Relative Strengths of Conjugate Acid-Base Pairs

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2020

Brønsted-Lowry acid-base chemistry is the transfer of protons; thus, logic suggests a relation between the relative strengths of conjugate acid-base pairs. The strength of an acid or base is quantified in its ionization constant, Ka or Kb, which represents the extent of the acid or base ionization reaction. For the conjugate acid-base pair HA / A−, the ionization equilibrium equations and ionization constant expressions are Adding these two chemical equations yields the equation for the...

Conjugated Proteins

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2020

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties. Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

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2025

Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme activation, sulfur...

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

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2025

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion. Several distinctive characteristics distinguish glutathione conjugation from other phase II...

Research

JoVE EoE - Gynecologic Cancer

Functionalized Nanoparticle Targeting of Ovarian Cancer: A Technique to Facilitate Folic Acid-conjugated Nanoparticle Contrast Agent Uptake by Ovarian Cancer Cells

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2023

In this video, we demonstrate a technique to facilitate the internalization of folic acid-capped copper sulfide nanoparticles (CuS NPs). Folic acid-functionalized CuS NPs have the ability to target folate-receptors which are overexpressed in many ovarian cancer cells.

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