Coronary Artery Bypass Grafting
Coronary Artery Bypass Grafting - Related Videos
09:09
Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
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2026
Coronary endarterectomy tissue samples were processed to isolate single nuclei using an optimized dissociation protocol. The integrity of the isolated nuclei was validated through three complementary approaches: trypan blue exclusion staining to assess membrane integrity, DAPI-based confocal microscopy to confirm nuclear morphology, and flow cytometry to quantify nuclear yield and purity.
13:10
Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)
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Cited by 7 •
2017
Surgical correction of ALCAPA is highly recommended, regardless of age or the degree of intercoronary collateralization. This protocol presents a technique for the direct re-implantation of adult-type ALCAPA into the aorta to re-establish the dual-coronary perfusion. Whenever feasible, direct re-implantation is preferred to other surgical correction techniques.
09:12
Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
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Cited by 10 •
2018
This protocol presents a surgical large animal model of chronic, single vessel ischemia that results in regional abnormalities but does not create infarct, known as hibernating myocardium. Following establishment of chronic ischemia, animals are treated with off-pump LIMA-LAD coronary artery bypass graft surgery to revascularize the ischemic tissue.
05:25
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
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Cited by 7 •
2023
This study presents a surgical porcine model of chronic myocardial ischemia due to progressive coronary artery stenosis, resulting in impaired cardiac function without infarction. Following ischemia, animals undergo off-pump coronary artery bypass graft with epicardial placement of stem cells-derived exosomes-laden collagen patch. This adjunctive therapy improves myocardial function and recovery.
05:47
Modified Technique for Coronary Artery Ligation in Mice
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Cited by 8 •
2013
The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.
FAQs
Graft selection identifies the healthy blood vessel used to create the bypass route. In CABG, the vessel may come from the chest, arm, or leg, and it is positioned to connect areas above and below a coronary obstruction. This selection is clinically important because the chosen vessel becomes the pathway intended to improve blood delivery to heart muscle.
Connecting the graft on both sides of the obstruction allows blood to flow around the diseased segment rather than through it. This rerouting can improve myocardial oxygen supply, which is relevant to the ischemia caused by reduced coronary blood flow. The mechanism explains how CABG can address both impaired perfusion and symptoms such as angina.
CABG is particularly relevant when coronary artery disease produces severe or multivessel disease, as well as when coronary arteries are significantly narrowed or blocked. The procedure therefore applies to clinical situations in which impaired blood flow affects a substantial portion of the coronary circulation. Its role is determined within the broader evaluation of cardiac function and cardiovascular status.
The procedure includes selecting and taking a healthy blood vessel from the chest, arm, or leg, then using that vessel as a graft. The graft is connected above and below the diseased coronary segment so blood can pass around the obstruction. These steps establish the new route responsible for improving blood flow to the myocardium.
Clinical evaluation after CABG can focus on relief of angina, reduction of ischemia, and improvement in myocardial oxygen supply. These outcomes indicate whether the new blood-flow route is addressing the effects of coronary artery disease. Assessment may also include cardiac function and longer-term cardiovascular outcomes, connecting immediate symptom changes with broader treatment results.
CABG provides a clinical setting for evaluating several interconnected issues: which graft source is selected, how cardiac function responds, how perioperative care is managed, and what long-term cardiovascular outcomes follow. Because the procedure is used for severe or multivessel coronary disease, it also helps clinical cardiology examine treatment results in patients with substantial impairment of coronary blood flow.